Formulation and In Vitro Characterization of Sustained Release Tablets of Lornoxicam

The aim of current study was to formulate controlled release tablet of lornoxicam. Various matrix based lornoxicam tablets were prepared through direct compression by varying the concentration of ethyl cellulose and methyl cellulose polymers. Compatibility of excipients with active was studied through FT-IR. Micromeritic properties of powder blends were determined and only those formulations exhibiting appropriate flow character were compressed. The physical parameters of tablets were evaluated and multiple point dissolution profile at pH 6.8 was obtained. Dissolution profile of formulations displaying controlled release profile was compared by model dependent and independent methods. FT-IR scans clearly reflect the compatibility of lornoxicam with all excipients. On the basis of physico-chemical characterization and controlled release pattern, LR6 was set to be optimized trial formulation. All trial lornoxicam sustained release formulations (LR1-LR6) obeyed zero-order and Higuchi release kinetics with non-fickian and anomalous transport (n = 0.706 to 1.117).