Common variation in Cholesteryl Ester Transfer Protein: Relationship of first major adverse cardiovascular events with the apolipoprotein B/apolipoprotein A-I ratio and the total cholesterol/high-density lipoprotein cholesterol ratio

被引：11

作者：

Kappelle, Paul J. W. H. ^{[1
]}

Gansevoort, Ron T. ^{[2
]}

Hillege, Hans J. ^{[3
]}

Wolffenbuttel, Bruce H. R. ^{[1
]}

Dullaart, Robin P. F. ^{[1
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Dept Endocrinol, NL-9700 RB Groningen, Netherlands

[2] Univ Groningen, Univ Med Ctr Groningen, Dept Nephrol, NL-9700 RB Groningen, Netherlands

[3] Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, NL-9700 RB Groningen, Netherlands

来源：

JOURNAL OF CLINICAL LIPIDOLOGY | 2013年 / 7卷 / 01期

关键词：

Apolipoprotein A-I; Apolipoprotein B; Cardiovascular risk; Cholesteryl Ester Transfer Protein gene; HDL cholesterol; Non-HDL cholesterol; PHOSPHOLIPID-TRANSFER-PROTEIN; TYPE-2; DIABETES-MELLITUS; PROMOTER POLYMORPHISM; PARTICLE-SIZE; CETP MASS; RISK; PLASMA; DISEASE; ASSOCIATION; ACYLTRANSFERASE;

D O I：

10.1016/j.jacl.2012.05.003

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

BACKGROUND: The preference of the apolipoprotein (apo) B/apoA-I ratio over the total cholesterol/HDL cholesterol (TC/HDL-C) ratio in cardiovascular risk prediction is disputed. Cholesteryl ester transfer protein (CETP) is instrumental in lipoprotein remodelling and affects the cholesterol content in pro- and antiatherogenic lipoproteins relative to their major apolipoproteins. We tested the influence of common CETP variations on the strength of associations of a first major adverse cardiovascular event (MACE) with the apoB/apoA-I ratio compared with the TC/HDL-C ratio. METHODS: A prospective case-cohort study was performed (PREVEND cohort; no previous cardiovascular disease and no use of lipid-lowering drugs initially). Fasting serum TC/HDL-C, apoB/ apoA-I, triglycerides, and common CETP variations (TaqIB [fs708272] and -629C>A [rs1800775] polymorphisms) were measured at baseline. The composite end point was incident MACE. RESULTS: A total of 532 of 6780 subjects experienced a first MACE during 10.8 years follow-up. The age- and sex-adjusted hazard ratio was 1.31 (95 % confidence interval 1.23-1.41) for the apoB/apoA-I ratio and 1.22(95% confidence interval 1.26-1.39) for the TC/HDL-C ratio (both P < .001). These relationships were essentially similar within each TaqIB and -629C>A CETP genotype group. No interactions of the apoB/apoA-I ratio and the TC/HDL-C ratio with the TaqIB and the -629C>A CETP variations on incident MACE were observed (P > .20 for all). CONCLUSION: The relationship of first MACE with the TC/HDL-C and the apoB/apoA-I ratio is not to an important extent dependent on common CETP variations. CETP variations are unlikely to affect the strength of the relationship of first MACE with the apoB/apoA-I ratio compared with the TC/HDL-C ratio. (C) 2013 National Lipid Association. All rights reserved.

引用

页码：56 / 64

页数：9

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