Palladium-catalyzed oxime ether directed regioselective C-H alkoxylation of arenes

被引：17

作者：

Pan, Liang ^{[1
]}

Wang, Liang ^{[1
]}

Chen, Qun ^{[1
]}

He, Mingyang ^{[1
]}

机构：

[1] Changzhou Univ, Sch Petrochem Engn, Changzhou 213164, Peoples R China

来源：

SYNTHETIC COMMUNICATIONS | 2016年 / 46卷 / 24期

基金：

中国国家自然科学基金;

关键词：

Acetoxylation; alkoxylation; C-H activation; oxime ethers; palladium catalysis; O-METHYL OXIMES; BOND ACTIVATION; ORTHO-ACYLATION; ARYL; FUNCTIONALIZATION; HYDROXYLATION; CONSTRUCTION; ALCOHOLS; STRATEGY; ACCESS;

D O I：

10.1080/00397911.2016.1242749

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A palladium-catalyzed highly regioselective ortho-C(sp(2))-H alkoxylation of oxime ethers with PhI(OAc)(2) as the oxidant and alcohols as the alkoxylation reagents has been developed. Mono-alkoxylated and acetoxylated products could be selectively obtained via tuning the reaction conditions. A series of oxime ethers were tolerated, affording the corresponding products in moderate to good yields. Both primary and secondary alcohols survived the reaction conditions. Moreover, the directing group can be easily removed, thereby providing a straightforward access to substituted aryl ketones.

引用

页码：1981 / 1988

页数：8

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