A Literature Review of the Potential Diagnostic Biomarkers of Head and Neck Neoplasms

被引：27

作者：

Konings, Heleen ^{[1
]}

Stappers, Sofie ^{[1
]}

Geens, Margot ^{[1
]}

De Winter, Benedicte Y. ^{[2
,3
]}

Lamote, Kevin ^{[2
,3
,4
,5
]}

van Meerbeeck, Jan P. ^{[2
,3
,4
,5
]}

Specenier, Pol ^{[6
,7
]}

Vanderveken, Olivier M. ^{[1
,8
,9
]}

Ledeganck, Kristien J. ^{[2
,3
]}

机构：

[1] Univ Antwerp, Fac Med & Hlth Sci, Antwerp, Belgium

[2] Univ Antwerp, Lab Expt Med & Pediat, Antwerp, Belgium

[3] Univ Antwerp, Infla Med Ctr Excellence, Antwerp, Belgium

[4] Antwerp Univ Hosp, Dept Pneumol, Edegem, Belgium

[5] Univ Ghent, Dept Internal Med & Pediat, Ghent, Belgium

[6] Antwerp Univ Hosp, Dept Oncol, Edegem, Belgium

[7] Univ Antwerp, Ctr Oncol Res CORE, Antwerp, Belgium

[8] Antwerp Univ Hosp, Dept Otorhinolaryngol Head & Neck Surg, Edegem, Belgium

[9] Antwerp Univ, Dept Translat Neurosci, Antwerp, Belgium

来源：

FRONTIERS IN ONCOLOGY | 2020年 / 10卷

关键词：

head and neck neoplasms; biomarker; genomics; proteomics; metabolomics; volatomics; microbiomics; radiomics; SQUAMOUS-CELL CARCINOMA; VOLATILE ORGANIC-COMPOUNDS; ELECTRONIC NOSE TECHNOLOGY; BARR-VIRUS DNA; NASOPHARYNGEAL CARCINOMA; EPITHELIAL DYSPLASIA; EXHALED BREATH; SCREENING TOOL; PET RADIOMICS; HUMAN SALIVA;

D O I：

10.3389/fonc.2020.01020

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Head and neck neoplasms have a poor prognosis because of their late diagnosis. Finding a biomarker to detect these tumors in an early phase could improve the prognosis and survival rate. This literature review provides an overview of biomarkers, covering the different -omics fields to diagnose head and neck neoplasms in the early phase. To date, not a single biomarker, nor a panel of biomarkers for the detection of head and neck tumors has been detected with clinical applicability. Limitations for the clinical implementation of the investigated biomarkers are mainly the heterogeneity of the study groups (e.g., small population in which the biomarker was tested, and/or only including high-risk populations) and a low sensitivity and/or specificity of the biomarkers under study. Further research on biomarkers to diagnose head and neck neoplasms in an early stage, is therefore needed.

引用

页数：18