Symptomatic Hepatitis B Virus (HBV) Reactivation despite Reduced Viral Fitness Is Associated with HBV Test and Immune Escape Mutations in an HIV-Coinfected Patient

被引：23
|
作者：
Henke-Gendo, Cornelia [1 ]
Amini-Bavil-Olyaee, Samad [2 ]
Challapalli, Deepthi [1 ]
Trautwein, Christian [2 ]
Deppe, Heidi [1 ]
Schulz, Thomas F. [1 ]
Heim, Albert [1 ]
Tacke, Frank [2 ]
机构：
[1] Hannover Med Sch, Inst Virol, D-30625 Hannover, Germany
[2] Univ Hosp Aachen, Med Clin 3, Rhein Westfal TH Aachen, Aachen, Germany
来源：
JOURNAL OF INFECTIOUS DISEASES | 2008年 / 198卷 / 11期
关键词：
D O I：
10.1086/592987
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Two sequential hepatitis B virus (HBV) strains obtained before and during an icteric flare-up of an occult HBV infection in a patient coinfected with human immunodeficiency virus revealed HBV surface antigen (HBsAg) test escape mutations, although the patient had never received hepatitis B-specific immunoglobulin. In contrast to the high HBV DNA loads, recurrence of HBsAg, and resulting icteric hepatitis, phenotypic analysis of the mutated HBV strains revealed significantly reduced replication efficacies in vitro, compared with wild-type HBV. Therefore, immune escape in the transiently anti-HBs positive patient appeared to be crucial for persistence and reactivation. Immune escape mutants evolved even without exogenous selective pressure, hampered detection in HBsAg screening, and might be transmitted during reactivation with high HBV loads.
引用
收藏
页码：1620 / 1624
页数：5
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