Anticancer activity of seaweeds

被引：114

作者：

Gutierrez-Rodriguez, Anliely G. ^{[1
,2
]}

Juarez-Portilla, Claudia ^{[1
]}

Olivares-Banuelos, Tatiana ^{[3
]}

Zepeda, Rossana C. ^{[1
]}

机构：

[1] Univ Veracruzana, Ctr Invest Biomed, Ave Dr Luis Castelazo Ayala S-N, Xalapa 91190, Veracruz, Mexico

[2] Univ Veracruzana, Programa Doctorado Ciencias Biomed, Ave Dr Luis Castelazo Ayala S-N, Xalapa 91190, Veracruz, Mexico

[3] Univ Autonoma Baja California, Inst Invest Oceanol, Km 103 Autopista Tijuana Ensenada,AP 453, Ensenada, Baja California, Mexico

来源：

DRUG DISCOVERY TODAY | 2018年 / 23卷 / 02期

关键词：

IN-VITRO; ANTIPROLIFERATIVE ACTIVITY; SULFATED POLYSACCHARIDE; ANTITUMOR-ACTIVITY; BROWN SEAWEEDS; STRUCTURAL CHARACTERISTICS; CLADOSIPHON-OKAMURANUS; KAPPAPHYCUS ALVAREZII; UNDARIA-PINNATIFIDA; CHEMICAL-STRUCTURE;

D O I：

10.1016/j.drudis.2017.10.019

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cancer is a major health problem worldwide and still lacks fully effective treatments. Therefore, alternative therapies, using natural products, have been proposed. Marine algae are an important component of the marine environment, with high biodiversity, and contain a huge number of functional compounds, including terpenes, polyphenols, phlorotannins, and polysaccharides, among others. These compounds have complex structures that have shown several biological activities, including anticancer activity, using in vitro and in vivo models. Moreover, seaweed-derived compounds target important molecules that regulate cancer processes. Here, we review our current understanding of the anticancer activity of seaweeds.

引用

页码：434 / 447

页数：14

共 91 条

[1]

Abd-Ellatef GEF, 2017, BREAST CANCER-TARGET, V9, P67, DOI 10.2147/BCTT.S125165

[2] Fucoidan induces apoptosis of human HS-Sultan cells accompanied by activation of caspase-3 and down-regulation of ERK pathways [J].

Aisa, Y ;

Miyakawa, Y ;

Nakazato, T ;

Shibata, H ;

Saito, K ;

Ikeda, Y ;

Kizaki, M .

AMERICAN JOURNAL OF HEMATOLOGY, 2005, 78 (01) :7-14

[3] Fucoidan from Sargassum sp and Fucus vesiculosus reduces cell viability of lung carcinoma and melanoma cells in vitro and activates natural killer cells in mice in vivo [J].

Ale, Marcel Tutor ;

Maruyama, Hiroko ;

Tamauchi, Hidekazu ;

Mikkelsen, Jorn D. ;

Meyer, Anne S. .

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2011, 49 (03) :331-336

[4] Antitumor and antimetastatic activity of fucoidan, a sulfated polysaccharide isolated from the Okhotsk sea Fucus evanescens brown alga [J].

Alekseyenko, T. V. ;

Zhanayeva, S. Ya. ;

Venediktova, A. A. ;

Zvyagintseva, T. N. ;

Kuznetsova, T. A. ;

Besednova, N. N. ;

Korolenko, T. A. .

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2007, 143 (06) :730-732

[5] High cytotoxicity and anti-proliferative activity of algae extracts on an in vitro model of human hepatocellular carcinoma [J].

Alves, Celso ;

Pinteus, Susete ;

Horta, Andre ;

Pedrosa, Rui .

SPRINGERPLUS, 2016, 5

[6]

[Anonymous], MOL CELL BI IN PRESS

[7]

[Anonymous], WHAT IS CANC

[8] Identification and in vitro anti-esophageal cancer activity of a series of halogenated monoterpenes isolated from the South African seaweeds Plocamium suhrii and Plocamium cornutum [J].

Antunes, Edith M. ;

Afolayan, Anthonia F. ;

Chiwakata, Maynard T. ;

Fakee, Jameel ;

Knott, Michael G. ;

Whibley, Catherine E. ;

Hendricks, Denver T. ;

Bolton, John J. ;

Beukes, Denzil R. .

PHYTOCHEMISTRY, 2011, 72 (08) :769-772

[9] The Magnitude of Global Marine Species Diversity [J].

Appeltans, Ward ;

Ahyong, Shane T. ;

Anderson, Gary ;

Angel, Martin V. ;

Artois, Tom ;

Bailly, Nicolas ;

Bamber, Roger ;

Barber, Anthony ;

Bartsch, Ilse ;

Berta, Annalisa ;

Blazewicz-Paszkowycz, Magdalena ;

Bock, Phil ;

Boxshall, Geoff ;

Boyko, Christopher B. ;

Brandao, Simone Nunes ;

Bray, Rod A. ;

Bruce, Niel L. ;

Cairns, Stephen D. ;

Chan, Tin-Yam ;

Cheng, Lanna ;

Collins, Allen G. ;

Cribb, Thomas ;

Curini-Galletti, Marco ;

Dahdouh-Guebas, Farid ;

Davie, Peter J. F. ;

Dawson, Michael N. ;

De Clerck, Olivier ;

Decock, Wim ;

De Grave, Sammy ;

de Voogd, Nicole J. ;

Domning, Daryl P. ;

Emig, Christian C. ;

Erseus, Christer ;

Eschmeyer, William ;

Fauchald, Kristian ;

Fautin, Daphne G. ;

Feist, Stephen W. ;

Fransen, Charles H. J. M. ;

Furuya, Hidetaka ;

Garcia-Alvarez, Oscar ;

Gerken, Sarah ;

Gibson, David ;

Gittenberger, Arjan ;

Gofas, Serge ;

Gomez-Daglio, Liza ;

Gordon, Dennis P. ;

Guiry, Michael D. ;

Hernandez, Francisco ;

Hoeksema, Bert W. ;

Hopcroft, Russell R. .

CURRENT BIOLOGY, 2012, 22 (23) :2189-2202

[10] Cytotoxicity effect of degraded and undegraded kappa and iota carrageenan in human intestine and liver cell lines [J].

Ariffin, Shahrul Hisham Zainal ;

Yeen, Wong Woan ;

Abidin, Intan Zarina Zainol ;

Wahab, Rohaya Megat Abdul ;

Ariffin, Zaidah Zainal ;

Senafi, Sahidan .

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2014, 14

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