Synthesis and Crystal Structure of (5-Hydroxy-6-methoxybenzofuran-3-yl)-(4-methoxyphenyl)methanone

被引：0

作者：

He Bi-Feng ^{[1
]}

Wei Yong ^{[1
]}

Li Xiao-Yan ^{[1
]}

Xie Yong ^{[1
]}

Luo Hua-Jun ^{[1
]}

Huang Nian-Yu ^{[1
]}

Deng Wei-Qiao ^{[1
]}

机构：

[1] China Three Gorges Univ, Coll Chem & Life Sci, Hubei Key Lab Nat Prod Res & Dev, Yichang 443002, Peoples R China

来源：

CHINESE JOURNAL OF STRUCTURAL CHEMISTRY | 2012年 / 31卷 / 11期

关键词：

benzofuran; X-ray diffraction; crystal structure; pi-pi stacking interaction; hydrogen bond;

D O I：

暂无

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Compound 1 (5-hydroxy-6-methoxybenzofuran-3-yl)(4-methoxyphenyl)methanone, C17H14O5, as a potential anti-breast cancer agent has been synthesized under microwave irradiation, which was further converted to (5,6-dihydroxybenzofuran-3-yl)(4-methoxyphenyl)methanone (2). The compounds were characterized by MS and NMR spectra. Meanwhile, the crystal of l was obtained and determined by X-ray single-crystal diffraction. Crystal data: monoclinic system, space group P2(1)/n, a = 8.908(6), b = 10.505(7), c = 15.452(11) angstrom, beta = 105.043(9)degrees, V = 1396.4(16) angstrom(3), Z = 4, F(000) = 624, D-c = 1.419 g/cm(3), mu = 0.105 mm(-1), R = 0.0513 and wR = 0.1246 for 14459 independent reflections (R-int = 0.0647) and 2488 observed ones (I > 2 sigma(I)). Intermolecular O-H center dot center dot center dot O and pi-pi stacking interactions contributed to the stability of the structure.

引用

页码：1608 / 1612

页数：5

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