Polyploid Giant Cancer Cells (PGCCs): The Evil Roots of Cancer

被引：115
作者：
Chen, Junsong [1 ,2 ]
Niu, Na [2 ]
Zhang, Jin [3 ]
Qi, Lisha [2 ,4 ]
Shen, Weiwei [2 ,5 ]
Donkena, Krishna Vanaja [2 ]
Feng, Zhenqing [1 ]
Liu, Jinsong [2 ]
机构：
[1] Nanjing Med Univ, Dept Pathol, Nanjing, Jiangsu, Peoples R China
[2] Univ Texas MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA
[3] Fourth Mil Med Univ, State Key Lab Canc Biol, Dept Pathol, Xijing Hosp, Xian, Shaanxi, Peoples R China
[4] Tianjin Canc Inst & Hosp, Dept Pathol, Tianjin, Peoples R China
[5] Fourth Mil Med Univ, Dept Oncol, Tangdu Hosp, Xian, Shaanxi, Peoples R China
来源：
CURRENT CANCER DRUG TARGETS | 2019年 / 19卷 / 05期
关键词：
Polyploid giant cancer cells; cancer stem cells; blastomere-like cancer stem cells; endoreplication; reprogramming; cell fusion; HUMAN EMBRYOS; TUMOR-CELLS; IN-VITRO; ENDOREPLICATION; CYTOKINESIS; SENESCENCE; MULTINUCLEATION; TRANSFORMATION; CHEMOTHERAPY; BLASTOMERES;
D O I：
10.2174/1568009618666180703154233
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Polyploidy is associated with increased cell size and is commonly found in a subset of adult organs and blastomere stage of the human embryo. The polyploidy is formed through endoreplication or cell fusion to support the specific need of development including earliest embryogenesis. Recent data demonstrated that Polyploid Giant Cancer Cells (PGCCs) may have acquired an activated early embryonic-like program in response to oncogenic and therapeutic stress to generate reprogrammed cancer cells for drug resistance and metastasis. Targeting PGCCs may open up new opportunities for cancer therapy.
引用
收藏
页码：360 / 367
页数：8
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