Polyploid Giant Cancer Cells (PGCCs): The Evil Roots of Cancer

被引：111

作者：

Chen, Junsong ^{[1
,2
]}

Niu, Na ^{[2
]}

Zhang, Jin ^{[3
]}

Qi, Lisha ^{[2
,4
]}

Shen, Weiwei ^{[2
,5
]}

Donkena, Krishna Vanaja ^{[2
]}

Feng, Zhenqing ^{[1
]}

Liu, Jinsong ^{[2
]}

机构：

[1] Nanjing Med Univ, Dept Pathol, Nanjing, Jiangsu, Peoples R China

[2] Univ Texas MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA

[3] Fourth Mil Med Univ, State Key Lab Canc Biol, Dept Pathol, Xijing Hosp, Xian, Shaanxi, Peoples R China

[4] Tianjin Canc Inst & Hosp, Dept Pathol, Tianjin, Peoples R China

[5] Fourth Mil Med Univ, Dept Oncol, Tangdu Hosp, Xian, Shaanxi, Peoples R China

来源：

CURRENT CANCER DRUG TARGETS | 2019年 / 19卷 / 05期

关键词：

Polyploid giant cancer cells; cancer stem cells; blastomere-like cancer stem cells; endoreplication; reprogramming; cell fusion; HUMAN EMBRYOS; TUMOR-CELLS; IN-VITRO; ENDOREPLICATION; CYTOKINESIS; SENESCENCE; MULTINUCLEATION; TRANSFORMATION; CHEMOTHERAPY; BLASTOMERES;

D O I：

10.2174/1568009618666180703154233

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Polyploidy is associated with increased cell size and is commonly found in a subset of adult organs and blastomere stage of the human embryo. The polyploidy is formed through endoreplication or cell fusion to support the specific need of development including earliest embryogenesis. Recent data demonstrated that Polyploid Giant Cancer Cells (PGCCs) may have acquired an activated early embryonic-like program in response to oncogenic and therapeutic stress to generate reprogrammed cancer cells for drug resistance and metastasis. Targeting PGCCs may open up new opportunities for cancer therapy.

引用

页码：360 / 367

页数：8

共 50 条

[1] Characterizing and targeting polyaneuploid/polyploid giant cancer cells (PACCs/PGCCs)
Tagal, Vural
Tambar, Uttam K.
Roth, Michael G.
Minna, John D.
CANCER RESEARCH, 2022, 82 (10)
[2] Autophagy modulating therapeutics inhibit ovarian cancer colony generation by polyploid giant cancer cells (PGCCs)
Bowers, Robert R.
Andrade, Maya F.
Jones, Christian M.
White-Gilbertson, Shai
Voelkel-Johnson, Christina
Delaney, Joe R.
BMC CANCER, 2022, 22 (01)
[3] Autophagy modulating therapeutics inhibit ovarian cancer colony generation by polyploid giant cancer cells (PGCCs)
Robert R. Bowers
Maya F. Andrade
Christian M. Jones
Shai White-Gilbertson
Christina Voelkel-Johnson
Joe R. Delaney
BMC Cancer, 22
[4] Dormant cancer cells and polyploid giant cancer cells: The roots of cancer recurrence and metastasis
Jiao, Yuqi
Yu, Yongjun
Zheng, Minying
Yan, Man
Wang, Jiangping
Zhang, Yue
Zhang, Shiwu
CLINICAL AND TRANSLATIONAL MEDICINE, 2024, 14 (02):
[5] Molecular cytogenetic characterization of Polyploid Giant Cancer Cells (PGCCs) in cytarabine-resistant AML cells
Chen, Pei-Yi
Lin, Yu-Xuan
Wu, Chia-Ling
Yen, Jui-Hung
EUROPEAN JOURNAL OF HUMAN GENETICS, 2024, 32 : 1251 - 1252
[6] Molecular cytogenetic characterization of Polyploid Giant Cancer Cells (PGCCs) in cytarabine-resistant AML cells
Chen, Pei-Yi
Lin, Yu-Xuan
Wu, Chia-Ling
Yen, Jui-Hung
EUROPEAN JOURNAL OF HUMAN GENETICS, 2024, 32 : 1251 - 1252
[7] Molecular cytogenetic characterization of Polyploid Giant Cancer Cells (PGCCs) in cytarabine-resistant AML cells
Lin, Yu Xuan
Yen, Jui Hung
Wu, Chia Ling
Lin, Liang In
Chen, Pei Yi
CANCER SCIENCE, 2025, 116 : 1596 - 1596
[8] Intratumor Heterogeneity and Treatment Resistance of Solid Tumors with a Focus on Polyploid/Senescent Giant Cancer Cells (PGCCs)
Mirzayans, Razmik
Murray, David
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (14)
[9] Polyploid giant cancer cells and cancer progression
Zhou, Xinyue
Zhou, Mingming
Zheng, Minying
Tian, Shifeng
Yang, Xiaohui
Ning, Yidi
Li, Yuwei
Zhang, Shiwu
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2022, 10
[10] Number of glioma polyploid giant cancer cells (PGCCs) associated with vasculogenic mimicry formation and tumor grade in human glioma
Qu, Yang
Zhang, Li
Rong, Zhe
He, Tao
Zhang, Sai
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2013, 32

← 1 2 3 4 5 →