Biology and trafficking of ATG9 and ATG16L1, two proteins that regulate autophagosome formation

被引：67
作者：
Zavodszky, Eszter [1 ]
Vicinanza, Mariella [1 ]
Rubinsztein, David C. [1 ]
机构：
[1] Univ Cambridge, Addenbrookes Hosp, Dept Med Genet, Cambridge Inst Med Res, Cambridge CB2 0XY, England
来源：
FEBS LETTERS | 2013年 / 587卷 / 13期
基金：
英国惠康基金;
关键词：
Autophagy; Atg9; Atg16; Phagophore; Membrane trafficking; GENOME-WIDE ASSOCIATION; SACCHAROMYCES-CEREVISIAE; ENDOPLASMIC-RETICULUM; LC3; LIPIDATION; CONJUGATION SYSTEM; ISOLATION MEMBRANE; CROHN-DISEASE; COMPLEX; YEAST; GOLGI;
D O I：
10.1016/j.febslet.2013.04.025
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Autophagy is a highly conserved intracytoplasmic degradation pathway for proteins, oligomers, organelles and pathogens. It initiates with the formation of a cup-shaped double membrane structure called the phagophore. The membrane origin for autophagosomes has been a key question for the field. ATG9 and ATG16L1, or their yeast orthologues, are key proteins that regulate autophagosome biogenesis, and may be associated with distinct membrane sources. Here we review the biology of autophagy with a focus on ATG16L1 and ATG9, and we summarise the current knowledge of their trafficking in relation to autophagic stimuli and autophagosome formation. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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收藏
页码：1988 / 1996
页数：9
相关论文
共 74 条
[1]   Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum [J].
Axe, Elizabeth L. ;
Walker, Simon A. ;
Manifava, Maria ;
Chandra, Priya ;
Roderick, H. Llewelyn ;
Habermann, Anja ;
Griffiths, Gareth ;
Ktistakis, Nicholas T. .
JOURNAL OF CELL BIOLOGY, 2008, 182 (04) :685-701
[2]   TMEM59 defines a novel ATG16L1-binding motif that promotes local activation of LC3 [J].
Boada-Romero, Emilio ;
Letek, Michal ;
Fleischer, Aarne ;
Pallauf, Kathrin ;
Ramon-Barros, Cristina ;
Pimentel-Muinos, Felipe X. .
EMBO JOURNAL, 2013, 32 (04) :566-582
[3]   SiRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy [J].
Chan, Edmond Y. W. ;
Kir, Serkan ;
Tooze, Sharon A. .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (35) :25464-25474
[4]   Kinase-Inactivated ULK Proteins Inhibit Autophagy via Their Conserved C- Terminal Domains Using an Atg13-Independent Mechanism [J].
Chan, Edmond Y. W. ;
Longatti, Andrea ;
McKnight, Nicole C. ;
Tooze, Sharon A. .
MOLECULAR AND CELLULAR BIOLOGY, 2009, 29 (01) :157-171
[5]   Dimeric Coiled-coil Structure of Saccharomyces cerevisiae Atg16 and Its Functional Significance in Autophagy [J].
Fujioka, Yuko ;
Noda, Nobuo N. ;
Nakatogawa, Hitoshi ;
Ohsumi, Yoshinori ;
Inagaki, Fuyuhiko .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (02) :1508-1515
[6]   The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy [J].
Fujita, Naonobu ;
Itoh, Takashi ;
Omori, Hiroko ;
Fukuda, Mitsunori ;
Noda, Takeshi ;
Yoshimori, Tamotsu .
MOLECULAR BIOLOGY OF THE CELL, 2008, 19 (05) :2092-2100
[7]   Differential Involvement of Atg16L1 in Crohn Disease and Canonical Autophagy ANALYSIS OF THE ORGANIZATION OF THE Atg16L1 COMPLEX IN FIBROBLASTS [J].
Fujita, Naonobu ;
Saitoh, Tatsuya ;
Kageyama, Shun ;
Akira, Shizuo ;
Noda, Takeshi ;
Yoshimori, Tamotsu .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (47) :32602-32609
[8]   Combinational Soluble N-Ethylmaleimide-sensitive Factor Attachment Protein Receptor Proteins VAMP8 and Vti1b Mediate Fusion of Antimicrobial and Canonical Autophagosomes with Lysosomes [J].
Furuta, Nobumichi ;
Fujita, Naonobu ;
Noda, Takeshi ;
Yoshimori, Tamotsu ;
Amano, Atsuo .
MOLECULAR BIOLOGY OF THE CELL, 2010, 21 (06) :1001-1010
[9]   Interaction between FIP200 and ATG16L1 distinguishes ULK1 complex-dependent and -independent autophagy [J].
Gammoh, Noor ;
Florey, Oliver ;
Overholtzer, Michael ;
Jiang, Xuejun .
NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2013, 20 (02) :144-149
[10]   Post-Golgi Sec Proteins Are Required for Autophagy in Saccharomyces cerevisiae [J].
Geng, Jiefei ;
Nair, Usha ;
Yasumura-Yorimitsu, Kyoko ;
Klionsky, Daniel J. .
MOLECULAR BIOLOGY OF THE CELL, 2010, 21 (13) :2257-2269
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