Type 1 Diabetes in Parents and Risk of Attention Deficit/Hyperactivity Disorder in Offspring: A Population-Based Study in Sweden

被引:31
作者
Ji, Jianguang [1 ]
Chen, Tianhui [2 ]
Sundquist, Jan [1 ,3 ]
Sundquist, Kristina [1 ,3 ]
机构
[1] Lund Univ Reg Skane, Ctr Primary Hlth Care Res, Lund, Sweden
[2] Zhejiang Acad Med Sci, Grp Mol Epidemiol & Canc Precis Prevent, Hangzhou, Zhejiang, Peoples R China
[3] Icahn Sch Med Mt Sinai, Dept Populat Hlth Sci & Policy, Dept Family Med & Community Hlth, New York, NY 10029 USA
基金
瑞典研究理事会; 国家重点研发计划;
关键词
CHILDHOOD; FERTILITY; ADHD; HYPERGLYCEMIA; CONSEQUENCES; METAANALYSIS; MELLITUS; CHILDREN; COHORT; TRENDS;
D O I
10.2337/dc17-0592
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVETo explore whether a family history of type 1 diabetes (T1D) is associated with an increased incidence of attention deficit/hyperactivity disorder (ADHD) in offspring.RESEARCH DESIGN AND METHODSIndividuals with T1D were identified from the nationwide Swedish National Hospital Discharge Register and Swedish Outpatient Register in Sweden and were linked to the Swedish Multi-Generation Register to identify their offspring. Cox regression was used to calculate the hazard ratio (HR) of ADHD in offspring of patients with T1D compared with the general population.RESULTSA total of 15,615 individuals were born after their parents were diagnosed with T1D. After a set of confounding factors was controlled for, offspring of T1D patients had a significantly increased risk of ADHD with an HR of 1.29 (95% CI 1.15-1.42). Maternal T1D was associated with an enhanced risk of ADHD (HR 1.35 [95% CI 1.18-1.55]) compared with paternal T1D (HR 1.20 [95% CI 1.03-1.41]), but the difference was not statistically significant.CONCLUSIONSIn this retrospective cohort study, we found that a parental history of T1D was associated with a 29% increased risk of being diagnosed with ADHD. However, the underlying mechanisms need to be explored in future studies.
引用
收藏
页码:770 / 774
页数:5
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