PTU-associated vasculitis in a girl with Turner syndrome and Graves' disease

被引:6
作者
Hardy, OT
Smolinski, KN
Yan, AC
Grimberg, A
机构
[1] Childrens Hosp Philadelphia, Div Endocrinol & Diabet, Philadelphia, PA 19104 USA
[2] Univ Penn, Dept Dermatol, Sch Med, Philadelphia, PA 19104 USA
[3] Univ Penn, Sch Med, Childrens Hosp Philadelphia, Dept Pediat & Dermatol,Sect Pediat Dermatol, Philadelphia, PA 19104 USA
[4] Univ Penn, Sch Med, Childrens Hosp Philadelphia, Dept Pediat,Div Endocrinol & Diabet, Philadelphia, PA 19104 USA
关键词
propylthiouracil (PTU); vasculitis; antineutrophil cytoplasmic antibody; hyperthyroidism; Graves' disease; Turner syndrome;
D O I
10.1097/01.pec.0000195763.42941.9f
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
\Palpable purpura is a concerning clinical finding in pediatric patients and can have many causes, including infectious and autoimmune processes. A rare cause, drug-induced vasculitis, may result from the production of antineutrophil cytoplasmic antibodies (ANCAs) in response to a medication. We report a girl with Turner syndrome and Graves' disease who presented with palpable purpuric lesions. The diagnosis of propylthiouracil (PTU)-associated vasculitis was made by observation of consistent clinical features, the detection of elevated ANA and ANCA in the blood, and the observed clinical resolution of symptoms following withdrawal of PTU. Subsequent treatment of persistent hyperthyroidism with radioablation did not result in an exacerbation of the vasculitis, a complication described in prior case reports.
引用
收藏
页码:52 / 54
页数:3
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