Phytochemical portfolio and anticancer activity of Murraya koenigii and its primary active component, mahanine

被引：36

作者：

Samanta, Suman Kumar ^{[1
]}

Kandimalla, Raghuram ^{[1
]}

Gogoi, Bhaskarjyoti ^{[1
]}

Dutta, Krishna Nayani ^{[1
]}

Choudhury, Paramita ^{[1
]}

Deb, Prashanta Kumar ^{[1
]}

Devi, Rajlakshmi ^{[1
]}

Pal, Bikas Chandra ^{[2
]}

Talukdar, Narayan Chandra ^{[1
]}

机构：

[1] Inst Adv Study Sci & Technol, Life Sci Div, Gauhati 781035, Assam, India

[2] Natl Inst Pharmaceut Educ & Res, Kolkata 700032, W Bengal, India

来源：

PHARMACOLOGICAL RESEARCH | 2018年 / 129卷

关键词：

Murraya koenigii; Mahanine; Anticancer; Chemical constituent; Bioactive; BREAST-CANCER CELLS; CARBAZOLE ALKALOIDS; O-METHYLMURRAYAMINE; METHANOLIC EXTRACT; INDUCED APOPTOSIS; ESSENTIAL OIL; CURRY LEAF; IN-VITRO; LEAVES; L;

D O I：

10.1016/j.phrs.2017.11.024

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Murraya koenigii, a plant belonging to the Rutaceae family is widely distributed in Eastern-Asia and its medicinal properties are well documented in Ayurveda, the traditional Indian system of medicine. Through systematic research and pharmacological evaluation of different parts of the plant extracts has been shown to possess antiviral, anti-inflammatory, antioxidant, antidiabetic, antidiarrhoeal, antileish-manial, and antitumor activity. In the plant extracts, carbazole alkaloid, mahanine has been identified as the principle bioactive component among several other chemical constituents. Scientific evidence derived not only from in vitro cellular experiments but also from in vivo studies in various cancer models is accumulating for the pronounced anticancer effects of mahanine. The primary objective of this review is to summarize research data on cytotoxic chemical constituents present in different parts of Murraya koenigii and the anticancer activity of mahanine along with the recent understanding on the mechanism of its action in diverse cancer models. The information on its bioavailability and the toxicity generated from the recent studies have also been incorporated in the review. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：227 / 236

页数：10

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