LAIR-1 overexpression and correlation with advanced pathological grade and immune suppressive status in oral squamous cell carcinoma

被引：23
|
作者：
Yang, Lei-Lei [1 ,2 ,3 ]
Zhang, Meng-Jie [4 ]
Wu, Lei [1 ,2 ]
Mao, Liang [1 ,2 ]
Chen, Lei [1 ,2 ]
Yu, Guang-Tao [1 ,2 ]
Deng, Wei-Wei [1 ,2 ]
Zhang, Wen-Feng [3 ]
Liu, Bing [3 ]
Sun, Wei-Ke [5 ]
Sun, Zhi-Jun [1 ,2 ,3 ]
机构：
[1] Wuhan Univ, Sch & Hosp Stomatol, State Key Lab Breeding Base Basic Sci Stomatol Hu, Wuhan, Hubei, Peoples R China
[2] Wuhan Univ, Sch & Hosp Stomatol, Key Lab Oral Biomed, Minist Educ, Wuhan, Hubei, Peoples R China
[3] Wuhan Univ, Sch & Hosp Stomatol, Dept Oral Maxillofacial Head Neck Oncol, Wuhan, Hubei, Peoples R China
[4] Jining Med Univ, Dept Stomatol, Jining, Peoples R China
[5] Binzhou Med Univ, Sch Stomatol, 346 Guanhai Rd, Binzhou 264003, Peoples R China
来源：
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2019年 / 41卷 / 04期
基金：
中国国家自然科学基金;
关键词：
immune checkpoint; immune suppression; LAIR-1; oral squamous cell carcinoma; tissue microarray; REGULATORY T-CELLS; IG-LIKE RECEPTOR-1; TUMOR-IMMUNITY; MYELOID CELLS; HEAD; EXPRESSION; DIFFERENTIATION; INFLAMMATION; ACTIVATION; BLOCKADE;
D O I：
10.1002/hed.25539
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Background This study aims to investigate the characteristic role of inhibitory receptor leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1) in oral squamous cell carcinoma (OSCC). Methods The expressions of LAIR-1 and other immune-related molecules were detected in a human OSCC tissue microarray. LAIR-1 expression difference among different clinicopathological parameters was analyzed. The correlations of LAIR-1 with several immune-related markers were assessed. Results Compared with dysplasia and oral mucosa, the expression of LAIR-1 was significantly upregulated in the stroma of OSCC, and its overexpression was correlated with advanced pathological grade. Overexpression of LAIR-1 was significantly associated with tumor-associated macrophage and myeloid-derived suppressor cell markers (CD68, CD163; CD33, CD11b), indoleamine 2,3-dioxygenase (IDO) and two immune checkpoints (B7-H3 and VISTA). Conclusions Overexpression of LAIR-1 was associated with advanced pathological grade and correlated with immune suppressive features in OSCC. Further studies are required to identify the specific immunological role of LAIR-1.
引用
收藏
页码：1080 / 1086
页数：7
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