LAIR-1 overexpression and correlation with advanced pathological grade and immune suppressive status in oral squamous cell carcinoma

被引：23
|
作者：
Yang, Lei-Lei [1 ,2 ,3 ]
Zhang, Meng-Jie [4 ]
Wu, Lei [1 ,2 ]
Mao, Liang [1 ,2 ]
Chen, Lei [1 ,2 ]
Yu, Guang-Tao [1 ,2 ]
Deng, Wei-Wei [1 ,2 ]
Zhang, Wen-Feng [3 ]
Liu, Bing [3 ]
Sun, Wei-Ke [5 ]
Sun, Zhi-Jun [1 ,2 ,3 ]
机构：
[1] Wuhan Univ, Sch & Hosp Stomatol, State Key Lab Breeding Base Basic Sci Stomatol Hu, Wuhan, Hubei, Peoples R China
[2] Wuhan Univ, Sch & Hosp Stomatol, Key Lab Oral Biomed, Minist Educ, Wuhan, Hubei, Peoples R China
[3] Wuhan Univ, Sch & Hosp Stomatol, Dept Oral Maxillofacial Head Neck Oncol, Wuhan, Hubei, Peoples R China
[4] Jining Med Univ, Dept Stomatol, Jining, Peoples R China
[5] Binzhou Med Univ, Sch Stomatol, 346 Guanhai Rd, Binzhou 264003, Peoples R China
来源：
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2019年 / 41卷 / 04期
基金：
中国国家自然科学基金;
关键词：
immune checkpoint; immune suppression; LAIR-1; oral squamous cell carcinoma; tissue microarray; REGULATORY T-CELLS; IG-LIKE RECEPTOR-1; TUMOR-IMMUNITY; MYELOID CELLS; HEAD; EXPRESSION; DIFFERENTIATION; INFLAMMATION; ACTIVATION; BLOCKADE;
D O I：
10.1002/hed.25539
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Background This study aims to investigate the characteristic role of inhibitory receptor leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1) in oral squamous cell carcinoma (OSCC). Methods The expressions of LAIR-1 and other immune-related molecules were detected in a human OSCC tissue microarray. LAIR-1 expression difference among different clinicopathological parameters was analyzed. The correlations of LAIR-1 with several immune-related markers were assessed. Results Compared with dysplasia and oral mucosa, the expression of LAIR-1 was significantly upregulated in the stroma of OSCC, and its overexpression was correlated with advanced pathological grade. Overexpression of LAIR-1 was significantly associated with tumor-associated macrophage and myeloid-derived suppressor cell markers (CD68, CD163; CD33, CD11b), indoleamine 2,3-dioxygenase (IDO) and two immune checkpoints (B7-H3 and VISTA). Conclusions Overexpression of LAIR-1 was associated with advanced pathological grade and correlated with immune suppressive features in OSCC. Further studies are required to identify the specific immunological role of LAIR-1.
引用
收藏
页码：1080 / 1086
页数：7
相关论文
共 50 条
  • [1] Neutrophils infiltration and its correlation with human papillomavirus status in the oral squamous cell carcinoma
    Li, Chen
    Zhao, Lei
    Wang, Qingjie
    Ma, Shao
    Sun, Jintang
    Ma, Chao
    Liu, Jia
    Jing, Xuanxuan
    Ai, Dan
    Nan, Zhaodi
    Qu, Xun
    CANCER MANAGEMENT AND RESEARCH, 2019, 11 : 5171 - 5185
  • [2] The pathological significance of Notch1 in oral squamous cell carcinoma
    Yoshida, Ryoji
    Nagata, Masashi
    Nakayama, Hideki
    Niimori-Kita, Kanako
    Hassan, Wael
    Tanaka, Takuji
    Shinohara, Masanori
    Ito, Takaaki
    LABORATORY INVESTIGATION, 2013, 93 (10) : 1068 - 1081
  • [3] Overexpression of PREX1 in oral squamous cell carcinoma indicates poor prognosis
    Wan, Shu-Cheng
    Wu, Hao
    Li, Hao
    Deng, Wei-Wei
    Xiao, Yao
    Wu, Cong-Cong
    Yang, Lei-Lei
    Zhang, Wen-Feng
    Sun, Zhi-Jun
    JOURNAL OF MOLECULAR HISTOLOGY, 2020, 51 (05) : 531 - 540
  • [4] Overexpression of Malic Enzyme 2 Indicates Pathological and Clinical Significance in Oral Squamous Cell Carcinoma
    Zhou, Jun-Jie
    Xiao, Yao
    Li, Hao
    Wu, Cong-Cong
    Chen, De-Run
    Chen, Lei
    Deng, Wei-Wei
    Zhang, Wen-Feng
    Sun, Zhi-Jun
    INTERNATIONAL JOURNAL OF MEDICAL SCIENCES, 2020, 17 (06): : 799 - 806
  • [5] CCND1 AMPLIFICATION AND PROTEIN OVEREXPRESSION IN ORAL SQUAMOUS CELL CARCINOMA OF YOUNG PATIENTS
    Kaminagakura, Estela
    da Cunha, Isabela Werneck
    Soares, Fernando Augusto
    Nishimoto, Ines Nobuko
    Kowalski, Luiz Paulo
    HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2011, 33 (10): : 1413 - 1419
  • [6] Increased Expression of SHMT2 Is Associated With Poor Prognosis and Advanced Pathological Grade in Oral Squamous Cell Carcinoma
    Wu, Zhi-Zhong
    Wang, Shuo
    Yang, Qi-Chao
    Wang, Xiao-Long
    Yang, Lei-Lei
    Liu, Bing
    Sun, Zhi-Jun
    FRONTIERS IN ONCOLOGY, 2020, 10
  • [7] Cyclin D1 overexpression and poor clinical outcomes in Taiwanese oral cavity squamous cell carcinoma
    Huang, Shiang-Fu
    Cheng, Sou-De
    Chuang, Wen-Yu
    Chen, I-How
    Liao, Chun-Ta
    Wang, Hung-Ming
    Hsieh, Ling-Ling
    WORLD JOURNAL OF SURGICAL ONCOLOGY, 2012, 10
  • [8] Cyclin B1 overexpression in conventional oral squamous cell carcinoma and verrucous carcinoma-A correlation with clinicopathological features
    Patil, Gururaj B.
    Hallikeri, Kaveri S.
    Balappanavar, Aswini Y.
    Hongal, Sudheer G.
    Sanjaya, P. R.
    Sagari, Sheetalkumar G.
    MEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL, 2013, 18 (04): : E585 - E590
  • [9] Overexpression of Hypoxia-Inducible Factor-1α and Its Relation with Aggressiveness and Grade of Oral Squamous Cell Carcinoma
    Sumera, Sumera
    Ali, Asif
    Yousafzai, Yasar M.
    Durrani, Zubair
    Alorini, Mohammed
    Aleem, Benish
    Zahir, Rabia
    DIAGNOSTICS, 2023, 13 (03)
  • [10] Overexpression of β-Adrenergic Receptors and the Suppressive Effect of β2-Adrenergic Receptor Blockade in Oral Squamous Cell Carcinoma
    Zhang, Chong
    Liao, Xianxiang
    Ma, Zhen
    Liu, Shiqi
    Fang, Fang
    Mai, Huaming
    JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 2020, 78 (10) : 1871.e1 - 1871.e23
12345