Rivaroxaban Therapy, False-Positive Lupus Anticoagulant Screening Results, and Confirmatory Assay Results

被引:6
作者
Murer, Lauren M. [1 ]
Pirruccello, Samuel J. [1 ]
Koepsell, Scott A. [1 ]
机构
[1] Univ Nebraska Med Ctr, Dept Pathol & Microbiol, Omaha, NE 68198 USA
关键词
rivaroxaban; lupus anticoagulant; antiphospholipid syndrome; DIRECT THROMBIN INHIBITORS; DEFINITE ANTIPHOSPHOLIPID SYNDROME; INTERNATIONAL CONSENSUS STATEMENT; CLASSIFICATION CRITERIA; UPDATE; TIME;
D O I
10.1093/labmed/lmw029
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Objective: To examine the effects of patients taking the direct blood coagulation factor Xa inhibitor rivaroxaban on lupus anticoagulant testing results in a clinical setting. Methods: We reviewed the results of lupus anticoagulant testing performed over a 2-year period. Of 59 patients who met criteria for a lupus anticoagulant, 18 were taking rivaroxaban. We reviewed and compared the parameters of lupus anticoagulant testing. Results: The average dilute Russell viper venom time (DRVVT) and normal plasma-mix screening results to confirmation ratios in rivaroxaban-naive patients were 1.6 and 1.7, respectively. In the rivaroxaban group, the same parameters were 1.7 and 1.6, respectively (P = -0.28 and 0.46, respectively). For 15 of 18 patients taking rivaroxaban, results were corrected on the confirmation steps of both tests. Conclusions: Rivaroxaban confounds lupus anticoagulant testing because the DRVVT is prolonged in these patients but it also corrects with excess phospholipid, mimicking a lupus anticoagulant. Patient medication review is critical to avoid false-positive findings and inappropriate diagnosis of antiphospholipid syndrome.
引用
收藏
页码:275 / 278
页数:4
相关论文
共 14 条
[11]   Detection of lupus anticoagulant in the presence of rivaroxaban using Taipan snake venom time [J].
Van Os, G. M. A. ;
De Laat, B. ;
Kamphuisen, P. W. ;
Meijers, J. C. M. ;
De Groot, Ph. G. .
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2011, 9 (08) :1657-1659
[12]  
Wilson WA, 1999, ARTHRITIS RHEUM, V42, P1309, DOI 10.1002/1529-0131(199907)42:7<1309::AID-ANR1>3.0.CO
[13]  
2-F
[14]   Laboratory diagnosis of the antiphospholipid syndrome [J].
Wisloff, F ;
Jacobsen, EM ;
Liestol, S .
THROMBOSIS RESEARCH, 2002, 108 (5-6) :263-271