Age-related changes in CD8 T cell homeostasis and immunity to infection

被引：98
作者：
Nikolich-Zugich, Janko
Li, Gang
Uhrlaub, Jennifer L.
Renkema, Kristin R.
Smithey, Megan J.
机构：
[1] Univ Arizona, Coll Med, Dept Immunobiol, Tucson, AZ 85724 USA
[2] Univ Arizona, Coll Med, Arizona Ctr Aging, Tucson, AZ 85724 USA
来源：
SEMINARS IN IMMUNOLOGY | 2012年 / 24卷 / 05期
关键词：
Aging; CD8 T cells; Immunity; Infection; Homeostasis; WEST-NILE-VIRUS; CD8-ALPHA(+) DENDRITIC CELLS; LISTERIA-MONOCYTOGENES INFECTION; HEALTHY ELDERLY POPULATION; CHRONIC VIRAL-INFECTION; HEPATITIS-C VIRUS; INFLUENZA VACCINATION; IFN-GAMMA; REPERTOIRE DIVERSITY; OLD MICE;
D O I：
10.1016/j.smim.2012.04.009
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Studies of CD8 T cell responses to vaccination or infection with various pathogens in both animal models and human subjects have revealed a markedly consistent array of age-related defects. In general, recent work shows that aged CD8 T cell responses are decreased in magnitude, and show poor differentiation into effector cells, with a reduced arsenal of effector functions. Here we review potential mechanisms underlying these defects. We specifically address phenotypic and numeric changes to the naive CD8 T cell precursor pool, the impact of persistent viral infection(s) and inflammation, and contributions of the aging environment in which these cells are activated. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：356 / 364
页数：9
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