Cycloartane triterpenoids from Astragalus bicuspis

被引：29
作者：
Choudhary, M. Iqbal [1 ]
Jan, Saleem [1 ]
Abbaskhan, Ahmed [1 ]
Musharraf, Syed Ghulam [1 ]
Samreen [1 ]
Sattar, Samina A. [1 ]
Atta-ur-Rahman [1 ]
机构：
[1] Univ Karachi, Int Ctr Chem & Biol Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan
来源：
JOURNAL OF NATURAL PRODUCTS | 2008年 / 71卷 / 09期
关键词：
D O I：
10.1021/np800161j
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Three new cycloartane glycosides have been isolated from Astragalus bicuspis. They were identified as 6 alpha-hydroxy3-O-beta-xylopyranosyloxy-24,25,26,27-tetranor-9,19-cyclolanosta-16,23-lactone (1), 6 alpha-hydroxy-23-methoxy-16 beta,23(R)epoxy-24,25,26,27-tetranor-9,19-cyclolanosta-3-O-beta-xyloside (2), and 23(R),24(S),25(R),26(S)-16 beta/23,23/26,24/25-triepoxy-6 alpha,26-dihydroxy-9,19-cyciolanosta-3-O-beta-xyloside (3), on the basis of their spectroscopic data. Two known cycloartane derivatives, 4 and 5, were also obtained from this plant. Compounds 2-5 were tested for leishmanicidal activity against Leishmania major promastigotes and for cytotoxicity against 3T3 cancer cells.
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页码：1557 / 1560
页数：4
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