Treatment of central venous catheter fungal infection using liposomal amphotericin-B lock therapy

被引：39

作者：

Buckler, Bradley S. ^{[1
]}

Sams, Ralph N. ^{[2
]}

Goei, Vita L. ^{[1
]}

Krishnan, Karthik R. ^{[1
]}

Bemis, Marci J. ^{[3
]}

Parker, Deidrea P. ^{[3
]}

Murray, Dennis L. ^{[1
]}

机构：

[1] Dept Pediat, Augusta, GA USA

[2] Med Coll Georgia, Sch Med, Augusta, GA 30912 USA

[3] Med Coll Georgia, Dept Pharm, Augusta, GA 30912 USA

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2008年 / 27卷 / 08期

关键词：

central venous catheters; fungal infections; liposomal amphotericin-B; antifungal lock therapy;

D O I：

10.1097/INF.0b013e318170b68b

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The current standard of care for a fungal central venous catheter infection in a pediatric patient usually requires removal without any other feasible options. Although removal may reduce the rate of Candida-associated complications, literature reviews question whether the outcomes of removal substantiate this being the standard of care. We report 6 cases of central venous catheter fungal infections treated with liposomal amphotericin-B lock therapy. These cases consisted of 4 patients, 2 of whom received recurrent therapy. In 4 of these cases, there was successful eradication of the infectious fungal agent, allowing continued use of the catheter. A controlled study of antifungal lock therapy should be considered as a potential alternative to removal.

引用

页码：762 / 764

页数：3

共 8 条

[1] Broviac catheter-related candidemia [J].