Nephrotic syndrome in infants and children: pathophysiology and management

被引：122

作者：

Downie, Mallory L. ^{[1
,2
]}

Gallibois, Claire ^{[3
]}

Parekh, Rulan S. ^{[1
,2
,3
,4
,5
,6
]}

Noone, Damien G. ^{[1
,2
]}

机构：

[1] Univ Toronto, Dept Paediat, Toronto, ON, Canada

[2] Hosp Sick Children, Div Nephrol, Toronto, ON, Canada

[3] Royal Coll Surgeons Ireland, Dept Med, Dublin, Ireland

[4] Hosp Sick Children, Res Inst, Child Hlth Evaluat Sci, Toronto, ON, Canada

[5] Univ Hlth Network, Div Nephrol, Toronto, ON, Canada

[6] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada

来源：

PAEDIATRICS AND INTERNATIONAL CHILD HEALTH | 2017年 / 37卷 / 04期

关键词：

Nephrotic syndrome; oedema; minimal change disease; focal segmental glomerulosclerosis; steroid-responsive nephrotic syndrome; steroid-resistant nephrotic syndrome; idiopathic nephrotic syndrome; FOCAL SEGMENTAL GLOMERULOSCLEROSIS; SOLUBLE UROKINASE RECEPTOR; MINIMAL CHANGE DISEASE; PERMEABILITY FACTOR; STEROID-RESISTANT; MYCOPHENOLATE-MOFETIL; ETHNIC-DIFFERENCES; KIDNEY-DISEASE; DOUBLE-BLIND; CYCLOPHOSPHAMIDE TREATMENT;

D O I：

10.1080/20469047.2017.1374003

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Nephrotic syndrome is defined by nephrotic-range proteinuria (>= 40 mg/m(2)/hour or urine protein/creatinine ratio >= 200 mg/mL or 3+ protein on urine dipstick), hypoalbuminaemia (< 25 g/L) and oedema. This review focuses on the classification, epidemiology, pathophysiology, management strategies and prognosis of idiopathic nephrotic syndrome of childhood, and includes a brief overview of the congenital forms.

引用

页码：248 / 258

页数：11

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