Nephrotic syndrome in infants and children: pathophysiology and management

被引:122
作者
Downie, Mallory L. [1 ,2 ]
Gallibois, Claire [3 ]
Parekh, Rulan S. [1 ,2 ,3 ,4 ,5 ,6 ]
Noone, Damien G. [1 ,2 ]
机构
[1] Univ Toronto, Dept Paediat, Toronto, ON, Canada
[2] Hosp Sick Children, Div Nephrol, Toronto, ON, Canada
[3] Royal Coll Surgeons Ireland, Dept Med, Dublin, Ireland
[4] Hosp Sick Children, Res Inst, Child Hlth Evaluat Sci, Toronto, ON, Canada
[5] Univ Hlth Network, Div Nephrol, Toronto, ON, Canada
[6] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada
关键词
Nephrotic syndrome; oedema; minimal change disease; focal segmental glomerulosclerosis; steroid-responsive nephrotic syndrome; steroid-resistant nephrotic syndrome; idiopathic nephrotic syndrome; FOCAL SEGMENTAL GLOMERULOSCLEROSIS; SOLUBLE UROKINASE RECEPTOR; MINIMAL CHANGE DISEASE; PERMEABILITY FACTOR; STEROID-RESISTANT; MYCOPHENOLATE-MOFETIL; ETHNIC-DIFFERENCES; KIDNEY-DISEASE; DOUBLE-BLIND; CYCLOPHOSPHAMIDE TREATMENT;
D O I
10.1080/20469047.2017.1374003
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Nephrotic syndrome is defined by nephrotic-range proteinuria (>= 40 mg/m(2)/hour or urine protein/creatinine ratio >= 200 mg/mL or 3+ protein on urine dipstick), hypoalbuminaemia (< 25 g/L) and oedema. This review focuses on the classification, epidemiology, pathophysiology, management strategies and prognosis of idiopathic nephrotic syndrome of childhood, and includes a brief overview of the congenital forms.
引用
收藏
页码:248 / 258
页数:11
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