Fast synchronized dual-wavelength laser speckle imaging system for monitoring hemodynamic changes in a stroke mouse model

被引：31

作者：

Qin, Jia ^{[1
]}

Shi, Lei ^{[1
]}

Dziennis, Suzan ^{[1
]}

Reif, Roberto ^{[1
]}

Wang, Ruikang K. ^{[1
]}

机构：

[1] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA

来源：

OPTICS LETTERS | 2012年 / 37卷 / 19期

基金：

美国国家卫生研究院;

关键词：

BLOOD-FLOW; CEREBRAL-ISCHEMIA; IN-VIVO; OXYGENATION; SPECTROSCOPY; REFLECTANCE; DYNAMICS; CORTEX;

D O I：

10.1364/OL.37.004005

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

In this Letter, we describe a newly developed synchronized dual-wavelength laser speckle contrast imaging system, which contains two cameras that are synchronously triggered to acquire data. The system can acquire data at a high spatiotemporal resolution (up to 500 Hz for similar to 1000 x 1000 pixels). A mouse model of stroke is used to demonstrate the capability for imaging the fast changes (within tens of milliseconds) in oxygenated and deoxygenated hemoglobin concentration, and the relative changes in blood flow in the mouse brain, through an intact cranium. This novel imaging technology will enable the study of fast hemodynamics and metabolic changes in vascular diseases. (C) 2012 Optical Society of America

引用

页码：4005 / 4007

页数：3

共 13 条

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