Miniaturized optical fiber tweezers for cell separation by optical force

被引：40

作者：

Liu, Shaojing ^{[1
]}

Li, Zongbao ^{[2
]}

Weng, Zhe ^{[1
]}

Li, Yuqi ^{[1
]}

Shui, Lingling ^{[1
]}

Jiao, Zhongxing ^{[3
]}

Chen, Yilin ^{[1
]}

Luo, Aiping ^{[1
]}

Xing, Xiaobo ^{[1
]}

He, Sailing ^{[1
]}

机构：

[1] South China Normal Univ, Coll Biophoton, MOE Key Lab Laser Life Sci, South China Acad Adv Optoelect, Guangzhou 510006, Guangdong, Peoples R China

[2] Tongren Univ, Sch Mat & Chem Engn, Tongren City 554300, Guizhou, Peoples R China

[3] Sun Yat Sen Univ, Sch Phys, Guangzhou 510275, Guangdong, Peoples R China

来源：

OPTICS LETTERS | 2019年 / 44卷 / 07期

基金：

中国国家自然科学基金;

关键词：

REFRACTIVE-INDEX; LASER TRAP; MANIPULATION; TRANSPORT; SYSTEM;

D O I：

10.1364/OL.44.001868

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

In advanced biomedicine and microfluidics, there is a strong desire to sort and manipulate various cells and bacteria based on miniaturized microfluidic chips. Here, by integrating fiber tweezers into a T-type microfluidic channel, we report an optofluidic chip to selectively trap Escherichia coli in human blood solution based on different sizes and shapes. Furthermore, we simulate the trapping and pushing regions of other cells and bacteria, including rod-shaped bacteria, sphere-shaped bacteria, and cancer cells based on finite-difference analysis. With the advantages of controllability, low optical power, and compact construction, the strategy may be possibly applied in the fields of optical separation, cell transportation, and water quality analysis. (C) 2019 Optical Society of America

引用

页码：1868 / 1871

页数：4

共 34 条

[1] FORCES OF A SINGLE-BEAM GRADIENT LASER TRAP ON A DIELECTRIC SPHERE IN THE RAY OPTICS REGIME [J].