Fabrication aspects of PLA-CaP/PLGA-CaP composites for orthopedic applications: A review

被引：216

作者：

Zhou, Huan ^{[1
]}

Lawrence, Joseph G. ^{[1
]}

Bhaduri, Sarit B. ^{[2
,3
]}

机构：

[1] Univ Toledo, Dept Bioengn, Toledo, OH 43606 USA

[2] Univ Toledo, Dept Mech Ind & Mfg Engn, Toledo, OH 43606 USA

[3] Univ Toledo, Dept Surg Dent, Toledo, OH 43606 USA

来源：

ACTA BIOMATERIALIA | 2012年 / 8卷 / 06期

基金：

美国国家科学基金会;

关键词：

PLA; PLGA; CaP; Composite; Fabrication; IN-VITRO DEGRADATION; L-LACTIC ACID; TISSUE ENGINEERING SCAFFOLDS; INDUCED PHASE-SEPARATION; FREE-FORM FABRICATION; POLY-L-LACTIDE; CALCIUM-PHOSPHATE; MECHANICAL-PROPERTIES; DRUG-DELIVERY; POROUS SCAFFOLDS;

D O I：

10.1016/j.actbio.2012.01.031

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

For several decades, composites made of polylactic acid-calcium phosphates (PLA-CaP) and polylactic acid-co-glycolic acid-calcium phosphates (PLGA-CaP) have seen widespread uses in orthopedic applications. This paper reviews the fabrication aspects of these composites, following the ubiquitous materials science approach by studying "processing-structure-property" correlations. Various fabrication processes such as microencapsulation, phase separation, electrospinning, supercritical gas foaming, etc., are reviewed, with specific examples of their applications in fabricating these composites. The effect of the incorporation of CaP materials on the mechanical and biological performance of PLA/PLGA is addressed. In addition, this paper describes the state of the art on challenges and innovations concerning CaP dispersion, incorporation of biomolecules/stem cells and long-term degradation of the composites. (C) 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

引用

页码：1999 / 2016

页数：18

共 50 条

[11] Recent research and development of PLGA/PLA microspheres/nanoparticles: A review in scientific and industrial aspects
Feng Qi
Jie Wu
Hao Li
Guanghui Ma
Frontiers of Chemical Science and Engineering, 2019, 13 : 14 - 27
[12] Recent research and development of PLGA/PLA microspheres/nanoparticles: A review in scientific and industrial aspects
Qi, Feng
Wu, Jie
Li, Hao
Ma, Guanghui
FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING, 2019, 13 (01) : 14 - 27
[13] Fabrication of Electrospun PLA-nHAp Nanocomposite for Sustained Drug Release in Dental and Orthopedic Applications
Kanak, Nishat Anzum
Shahruzzaman, Md.
Islam, Md. Sazedul
Takafuji, Makoto
Rahman, Mohammed Mizanur
Kabir, Sumaya F.
MATERIALS, 2023, 16 (10)
[14] Insight of magnesium alloys and composites for orthopedic implant applications - a review
Radha, R.
Sreekanth, D.
JOURNAL OF MAGNESIUM AND ALLOYS, 2017, 5 (03) : 286 - 312
[15] Bone Scintigraphy: A Review of Technical Aspects and Applications in Orthopedic Surgery
Krumme, John W.
Lauer, Madelyn F.
Stowell, Justin T.
Beteselassie, Nebiyu M.
Kotwal, Suhel Y.
ORTHOPEDICS, 2019, 42 (01) : E14 - E24
[16] Combining three-dimensionality and CaP glass-PLA composites: Towards an efficient vascularization in bone tissue healing
Ximenes-Carballo, Celia
Rey-Vinolas, Sergi
Blanco-Fernandez, Barbara
Perez-Amodio, Soledad
Engel, Elisabeth
Castano, Oscar
BIOMATERIALS ADVANCES, 2024, 164
[17] FABRICATION ASPECTS OF GLASS MATRIX COMPOSITES FOR GAS-TURBINE APPLICATIONS
CLARKE, DA
INSTITUTE OF PHYSICS CONFERENCE SERIES, 1990, (111): : 173 - 183
[18] Studies on parametric optimization of PLA/graphene composites synthesized by fused filament fabrication for thermal applications
Bashir, Muhammad Nasir
Logesh, K.
Kannan, Sathish
Vijayan, D. S.
Kumar, S. Suresh
Al Obaid, Sami
Lee, Joon Sang
THERMAL SCIENCE AND ENGINEERING PROGRESS, 2024, 54
[19] Titanium-Based alloys and composites for orthopedic implants Applications: A comprehensive review
Abd-Elaziem, Walaa
Darwish, Moustafa A.
Hamada, Atef
Daoush, Walid M.
MATERIALS & DESIGN, 2024, 241
[20] Silica aerogels; a review of synthesis, applications and fabrication of hybrid composites
Faheem Akhter
Suhail Ahmed Soomro
Vassilis J. Inglezakis
Journal of Porous Materials, 2021, 28 : 1387 - 1400

← 1 2 3 4 5 →