Reduced tolerance to certain pharmacological effects of ethanol after chronic administration in perinatally undernourished rats

被引:7
|
作者
Cordoba, NE [1 ]
Borghese, CM [1 ]
Arolfo, MP [1 ]
Orsingher, OA [1 ]
机构
[1] UNIV NACL CORDOBA,FAC CIENCIAS QUIM,DEPT FARMACOL,RA-5000 CORDOBA,ARGENTINA
关键词
perinatal undernutrition; chronic ethanol; tolerance; hypothermia; hypoalgesia; anticonvulsant; rat;
D O I
10.1016/S0091-3057(96)00392-9
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
We have previously reported that recovered adult rats undernourished at perinatal age failed to develop tolerance to the anticonflict effect of ethanol after chronic ethanol administration (1 g/kg/day during 30 days) (4). To further study the extent of this finding, we examined the effect of a similar chronic ethanol treatment on the hypothermic and anticonvulsant effects of ethanol in perinatally deprived rats. Hypoalgesic activity was assessed in ethanol treated rats during 15 days. After chronic ethanol treatment, a similar development of tolerance to the hypothermic effect of ethanol was observed in control and deprived rats. However, tolerance to the anticonvulsant and hypoalgesic effect of ethanol was significantly reduced in deprived as compared with control animals. Thus, early undernutrition differentially affects the development of tolerance elicited by chronic ethanol administration. (C) 1997 Elsevier Science Inc.
引用
收藏
页码:659 / 663
页数:5
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