A Unique Industrial - Academic Collaboration Towards the Next Generation of Schizophrenia Therapeutics

被引:8
作者
Macdonald, Gregor J. [1 ]
Lindsley, Craig W. [2 ,3 ]
机构
[1] Janssen Res & Dev, Neurosci Med Chem, B-2340 Beerse, Belgium
[2] Vanderbilt Univ Sch Med, Dept Pharmacol, Vanderbilt Ctr Neurosci Drug Discovery, Nashville, TN 37232 USA
[3] Vanderbilt Univ, Dept Chem, Nashville, TN 37232 USA
关键词
Metabotropic; mGlu(5); schizophrenia; allosteric; positive allosteric modulator; glutamate; NMDA hypofunction; RECEPTOR SUBTYPE 5; POSITIVE ALLOSTERIC MODULATORS; METABOTROPIC GLUTAMATE RECEPTORS; IN-VIVO ACTIVITY; ANTIPSYCHOTIC-LIKE; RECENT PROGRESS; DISCOVERY; HYPOTHESIS; PHARMACOLOGY; SERIES;
D O I
10.2174/1568026613666131127154443
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
This article describes the unique industrial - academic collaboration that has been running for four years between Janssen Pharmaceutica NV and the Vanderbilt Center for Neuroscience Drug Discovery (VCNDD) towards identifying the next generation of schizophrenia therapeutics. This was a true collaboration, with both entities engaged in chemistry, In vitro pharmacology, DMPK and In vivo behavioral pharmacology, and aligned to deliver a first-in-class clinical candidate (NME) and additional back-up molecules. Notably, a first NME was delivered in a rapid timeframe and targeted the novel mechanism of mGlu(5) positive allosteric modulation. As with any true collaboration, both sides brought unique skills to the table - Janssen leveraged deep drug discovery expertise and infrastructure, while Vanderbilt brought deep knowledge of the chemistry and pharmacology of the target in addition to the ability to provide deep scientific insight into the mechanism behind target modulation. In this article, we will discuss the science which drove our collaboration as well as some key lessons learned.
引用
收藏
页码:304 / 312
页数:9
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