Synthesis, characterization, and DNA binding of a novel ligand and its Cu(II) complex

被引：26
|
作者：
Li, Mei-Jin [1 ,2 ]
Lan, Tao-Yu [1 ]
Lin, Zhi-Shan [1 ]
Yi, Changqing [3 ]
Chen, Guo-Nan [1 ]
机构：
[1] Fuzhou Univ, Dept Chem, Minist Educ & Fujian Prov, Key Lab Anal & Detect Technol Food Safety, Fuzhou 350108, Peoples R China
[2] Chinese Acad Sci, Inst High Energy Phys, Beijing Synchrotron Radiat Lab, Beijing 100039, Peoples R China
[3] Sun Yat Sen Univ, Sch Engn, Guangzhou 510275, Guangdong, Peoples R China
来源：
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY | 2013年 / 18卷 / 08期
关键词：
Copper(II) complex; DNA binding; Cytotoxicity; Nucleolytic cleavage; G-QUADRUPLEX-DNA; NUCLEIC-ACIDS; TELOMERASE; INHIBITION; DERIVATIVES; STABILIZATION; PHOTOCLEAVAGE; TRANSITION; DESIGN; DUPLEX;
D O I：
10.1007/s00775-013-1048-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A novel naphthalene-2,3-diamine-2-salicylaldehyde (NS) ligand and its mononuclear copper(II) complex (CuNS) have been synthesized and structurally characterized. The UV-vis absorption and emission spectra of NS showed obvious changes on addition of Cu2+ solution. The interaction of the compounds with calf thymus DNA and G-quadruplex DNA were investigated by spectroscopic methods and thermal melting assay. The nucleolytic cleavage activity of the compounds was investigated on double-stranded circular pBR322 plasmid DNA and G-quadruplex DNA by electrophoretic mobility shift assay. The results show that CuNS has a greater ability to stabilize G-quadruplex DNA over calf-thymus DNA. The cytotoxicity of the compounds toward HpeG2 cancer cells was also studied, and they showed significant potential for antineoplastic effects.
引用
收藏
页码：993 / 1003
页数：11
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