tert-Butoxycarbonyl Chloride for the Introduction of N-Boc Groups into Amino Acids

被引：2

作者：

Vorbrueggen, Helmut ^{[1
,2
]}

机构：

[1] Woodward Res Inst, CH-4000 Basel, Switzerland

[2] Free Univ Berlin, Inst Chem & Biochem, D-14195 Berlin, Germany

来源：

SYNTHESIS-STUTTGART | 2008年 / 23期

关键词：

Boc chloride; COCl2; pyridine; mixed anhydrides; amino acids;

D O I：

10.1055/s-0028-1083227

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

tert-Butoxycarbonyl chloride (BocCI) call be generated in situ from tert-butyl alcohol. COCl2, and pyridine at -74 degrees C to introduce the Boc group in high yield into a hindered amino acid. The method is Suitable for large-scale preparations of Boc-amino acids.

引用

页码：3739 / 3741

页数：3

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