IL-21: An Executor of B Cell Fate

被引：129
作者：
Konforte, Danijela [1 ,3 ]
Simard, Nathalie [1 ,3 ]
Paige, Christopher J. [1 ,2 ,3 ]
机构：
[1] Univ Hlth Network, Princess Margaret Hosp, Ontario Canc Inst, Div Stem Cell & Dev Biol, Toronto, ON M5G 2M9, Canada
[2] Univ Toronto, Dept Med Biophys, Toronto, ON, Canada
[3] Univ Toronto, Dept Immunol, Toronto, ON, Canada
来源：
JOURNAL OF IMMUNOLOGY | 2009年 / 182卷 / 04期
基金：
加拿大健康研究院;
关键词：
FOLLICULAR-HELPER-CELLS; SYSTEMIC-LUPUS-ERYTHEMATOSUS; CLASS-SWITCH RECOMBINATION; IGE PRODUCTION; T-CELLS; SOMATIC HYPERMUTATION; RHEUMATOID-ARTHRITIS; HUMAN NAIVE; TH17; CELLS; INTERLEUKIN-21;
D O I：
10.4049/jimmunol.0803009
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
IL-21 is a type I cytokine that shares the common receptor gamma-chain with IL-2, IL-4, IL-7, IL-9, and IL-15. B cells are one of the lymphoid cell types whose development and function are regulated by IL-21. Depending on the interplay with costimulatory signals and on the developmental stage of a B cell, IL-21 can induce proliferation, differentiation into Ig-producing plasma cells, or apoptosis in both mice and humans. Alone and in combination with Th cell-derived cytokines IL-21 can regulate class switch recombination to IgG, IgA, or IgE isotypes, indicating its important role in shaping the effector function of B cells. This review highlights the role of IL-21 in B cell development, function, and disease and provides some perspectives on the future studies in this area. The Journal of Immunology, 2009, 182: 1781-1787.
引用
收藏
页码：1781 / 1787
页数：7
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