Evolutionary principles of modular gene regulation in yeasts

被引：47

作者：

Thompson, Dawn A. ^{[1
]}

Roy, Sushmita ^{[1
,2
]}

Chan, Michelle ^{[1
,3
]}

Styczynski, Mark P. ^{[1
]}

Pfiffner, Jenna ^{[1
]}

French, Courtney ^{[1
]}

Socha, Amanda ^{[1
]}

Thielke, Anne ^{[1
]}

Napolitano, Sara ^{[1
]}

Muller, Paul ^{[1
]}

Kellis, Manolis ^{[2
]}

Konieczka, Jay H. ^{[1
]}

Wapinski, Ilan ^{[1
]}

Regev, Aviv ^{[1
,4
]}

机构：

[1] Broad Inst MIT & Harvard, Cambridge, MA USA

[2] MIT, Comp Sci & Artificial Intelligence Lab, Cambridge, MA 02139 USA

[3] MIT, Computat & Syst Biol Program, Cambridge, MA 02139 USA

[4] MIT, Howard Hughes Med Inst, Dept Biol, Cambridge, MA USA

来源：

ELIFE | 2013年 / 2卷

基金：

美国国家卫生研究院;

关键词：

TRANSCRIPTION FACTOR-BINDING; EXPRESSION; DUPLICATION; DIVERGENCE; REVEALS; NETWORKS; CONSERVATION; FAMILY; GROWTH; SITES;

D O I：

10.7554/eLife.00603

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Divergence in gene regulation can play a major role in evolution. Here, we used a phylogenetic framework to measure mRNA profiles in 15 yeast species from the phylum Ascomycota and reconstruct the evolution of their modular regulatory programs along a time course of growth on glucose over 300 million years. We found that modules have diverged proportionally to phylogenetic distance, with prominent changes in gene regulation accompanying changes in lifestyle and ploidy, especially in carbon metabolism. Paralogs have significantly contributed to regulatory divergence, typically within a very short window from their duplication. Paralogs from a whole genome duplication (WGD) event have a uniquely substantial contribution that extends over a longer span. Similar patterns occur when considering the evolution of the heat shock regulatory program measured in eight of the species, suggesting that these are general evolutionary principles.

引用

页数：37

共 72 条

[1] Protein Modularity, Cooperative Binding, and Hybrid Regulatory States Underlie Transcriptional Network Diversification [J].