EUS 2008 Working Group document: evaluation of EUS-guided celiac plexus neurolysis/block (with video)

Celiac plexus neurolysis (CPN) has been performed for almost 100 years as a means of alleviating pain of pancreatic or retroperitoneal origin, and a variety of techniques, routes, and chemical agents have been used to maximize efficacy and minimize complications.(1-3) Until recently, CPN has been most commonly performed under fluoroscopic or CT guidance by using either a bilateral posterior or an anterior approach, and numerous studies confirmed the efficacy of the procedure and highlighted potential advantages over opioid therapy 45 In the last 10 years, EUS-guided CPN (EUS-CPN)/EUS-guided celiac plexus block (EUS-CPB) has been described as an alternative approach and is now widely practiced. This section of the EUS 2008 Working Group Proceedings evaluates the current evidence and potential for future research in this area.