Risk of depression and other mental health disorders in women with polycystic ovary syndrome: a longitudinal study

被引:141
|
作者
Kerchner, Angela [2 ]
Lester, Whitney [3 ]
Stuart, Scott P. [3 ]
Dokras, Anuja [1 ]
机构
[1] Univ Penn, Dept Obstet & Gynecol, Philadelphia, PA 19104 USA
[2] Univ Iowa, Roy J & Lucille A Carver Coll Med, Dept Obstet & Gynecol, Iowa City, IA USA
[3] Univ Iowa, Roy J & Lucille A Carver Coll Med, Dept Psychiat, Iowa City, IA USA
关键词
Polycystic ovary syndrome; depression; mood disorders; QUALITY-OF-LIFE; PRIME-MD; PREVALENCE; QUESTIONNAIRE; PREDICTORS; VALIDITY; UTILITY;
D O I
10.1016/j.fertnstert.2007.11.022
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: To determine the conversion risk and predictors for depression in women with polycystic ovary syndrome. Design: Prospective longitudinal study. Setting: University practice. Patient(s): Subjects with polycystic ovary syndrome who had participated in a previous study. Intervention(s): None. Main Outcome Measure(s): The Primary Care Evaluation of Mental Disorders Patient Health Questionnaire was used to diagnose major depressive disorder and other depressive syndromes, anxiety syndromes, and binge eating disorder. Subjects completed a questionnaire on knowledge about polycystic ovary syndrome and treatment satisfaction. Result(s): A total of 60 of 103 subjects responded to the second survey. Mean time between the two surveys was 22 months (range 12-26 months), The overall prevalence of depression was 40% (24/60). Of these, 10 women screened positive for major depressive disorder or other depressive syndromes and 14 were receiving antidepressant medications. There were 11 new cases identified in the second survey (19% conversion). Total subjects with mood disorders in this study were 34/60 (56.6%), including 11.6% with anxiety syndromes and 23.3% with binge eating disorder. Difficulties with menstrual function, fertility, and body image (weight, hirsutism, acne) were not significantly different in women with and without depression. Conclusion(s): There is a significant risk for mood disorders (defined by the Diagnostic and Statistical Manual of Mental Disorders-IV) in women with polycystic ovary syndrome. This finding together with a high conversion risk for depression over a 1- to 2-year period underscores the importance of routine screening and aggressive treatment of mental health disorders in this population. (Fertil Steril (R) 2009;91:207-12. (c) 2009 by American Society for Reproductive Medicine.)
引用
收藏
页码:207 / 212
页数:6
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