Synthesis, spectral characterization and catalytic activity of Co(II) complexes of drugs: Crystal structure of Co(II)-trimethoprim complex

被引：10

作者：

Madhupriya, Selvaraj ^{[1
]}

Elango, Kuppanagounder P. ^{[1
]}

机构：

[1] Deemed Univ, Gandhigram Rural Inst, Dept Chem, Gandhigram 624302, India

来源：

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2014年 / 118卷

关键词：

Co(II) complex; Drugs; Catalytic activity; ARYL GRIGNARD-REAGENTS; SCHIFF-BASE; METAL-COMPLEXES; ZINC(II) COMPLEXES; DNA-BINDING; NICKEL(II); COBALT(II); TRIMETHOPRIM; BIARYLS; NI(II);

D O I：

10.1016/j.saa.2013.08.085

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

New Co(II) complexes with drugs such as trimethoprim (TMP), cimetidine (CTD), niacinamide (NAM) and ofloxacin (OFL) as ligands were synthesized. The complexes were characterized by analytical analysis, various spectral techniques such as FT-IR, UV-Vis, magnetic measurements and molar conductivity. The magnetic susceptibility results coupled with the electronic spectra suggested a tetrahedral geometry for the complexes. The coordination mode of trimethoprim ligand and geometry of the complex were confirmed by single crystal X-ray studies. In this complex the metal ion possesses a tetrahedral geometry with two nitrogen atom from two TMP ligands and two chloride ions coordinated to it. The catalytic activity of the complexes in aryl-aryl coupling reaction was screened and the results indicated that among the four complexes [Co(OFL)Cl(H2O)] exhibited excellent catalytic activity. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：337 / 342

页数：6

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