Hereditary Breast/Ovarian Cancer Syndrome A Primer for Obstetricians/Gynecologists

被引：8
作者：
Meaney-Delman, Dana [1 ]
Bellcross, Cecelia A. [1 ]
机构：
[1] Emory Univ, Sch Med, Dept Gynecol & Obstet, Atlanta, GA 30303 USA
来源：
OBSTETRICS AND GYNECOLOGY CLINICS OF NORTH AMERICA | 2013年 / 40卷 / 03期
关键词：
BRCA1; BRCA2; Hereditary breast cancer; Hereditary ovarian cancer; Genetic testing; Clinical management; BRCA2 MUTATION CARRIERS; REDUCING SALPINGO-OOPHORECTOMY; CONTRALATERAL BREAST-CANCER; FAMILIAL-OVARIAN-CANCER; BILATERAL PROPHYLACTIC MASTECTOMY; HORMONE REPLACEMENT THERAPY; SURGICAL ADJUVANT BREAST; QUALITY-OF-LIFE; RISK-ASSESSMENT; FALLOPIAN-TUBE;
D O I：
10.1016/j.ogc.2013.05.009
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
An understanding of the diagnosis and clinical management of hereditary breast and ovarian cancer syndrome (HBOC) is essential for obstetricians/gynecologists. This article provides practical information regarding collecting a family history, cancer risk assessment and genetic testing, BRCA-associated cancer prognosis and treatment, screening recommendations, and prevention strategies. Through appropriate cancer risk assessment, women with BRCA1/2 mutations can be identified, and screening and prevention strategies can be used before a diagnosis of cancer occurs. Women's health providers with a strong working knowledge of HBOC are able to improve the quality of care for women and families impacted by BRCA1/2 mutations.
引用
收藏
页码：475 / +
页数：39
相关论文
共 203 条
  • [1] Associations of High-Grade Prostate Cancer with BRCA1 and BRCA2 Founder Mutations
    Agalliu, Ilir
    Gern, Robert
    Leanza, Suzanne
    Burk, Robert D.
    [J]. CLINICAL CANCER RESEARCH, 2009, 15 (03) : 1112 - 1120
  • [2] Unexpected gynecologic neoplasms in patients with proven or suspected BRCA-1 or-2 mutations - Implications for gross examination, cytology, and clinical follow-up
    Agoff, SN
    Mendelin, JE
    Grieco, VS
    Garcia, RL
    [J]. AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2002, 26 (02) : 171 - 178
  • [3] Pregnancies, breast-feeding, and breast cancer risk in the international BRCA1/2 carrier cohort study (IBCCS)
    Andrieu, Nadine
    Goldgar, David E.
    Easton, Douglas F.
    Rookus, Matti
    Brohet, Richard
    Antoniou, Antonis C.
    Peock, Susan
    Evans, Gareth
    Eccles, Diana
    Douglas, Fiona
    Nogues, Catherine
    Gauthier-Villars, Marion
    Chompret, Agnes
    van Leeuwen, Flora E.
    Kluijt, Irina
    Benitez, Javier
    Arver, Brita
    Olah, Edith
    Chang-Claude, Jenny
    [J]. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2006, 98 (08): : 535 - 544
  • [4] [Anonymous], 1998, Contracept Technol Update, V19, P146
  • [5] [Anonymous], 2009, Obstet Gynecol, V113, P957, DOI 10.1097/AOG.0b013e3181a106d4
  • [6] [Anonymous], CLIN PRACT GUID ONC
  • [7] [Anonymous], SCI TRANSL MED
  • [8] Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history:: A combined analysis of 22 studies
    Antoniou, A
    Pharoah, PDP
    Narod, S
    Risch, HA
    Eyfjord, JE
    Hopper, JL
    Loman, N
    Olsson, H
    Johannsson, O
    Borg, Å
    Pasini, B
    Radice, P
    Manoukian, S
    Eccles, DM
    Tang, N
    Olah, E
    Anton-Culver, H
    Warner, E
    Lubinski, J
    Gronwald, J
    Gorski, B
    Tulinius, H
    Thorlacius, S
    Eerola, H
    Nevanlinna, H
    Syrjäkoski, K
    Kallioniemi, OP
    Thompson, D
    Evans, C
    Peto, J
    Lalloo, F
    Evans, DG
    Easton, DF
    [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2003, 72 (05) : 1117 - 1130
  • [9] RAD51 135G→C modifies breast cancer risk among BRCA2 mutation carriers:: Results from a combined analysis of 19 studies
    Antoniou, Antonis C.
    Sinilnikova, Olga M.
    Simard, Jacques
    Leone, Melanie
    Dumont, Martine
    Neuhausen, Susan L.
    Struewing, Jeffery P.
    Stoppa-Lyonnet, Dominique
    Barjhoux, Laure
    Hughes, David J.
    Coupier, Isabelle
    Belotti, Muriel
    Lasset, Christine
    Rebbeck, Timothy R.
    Wagner, Theresa
    Lynch, Henry T.
    Domchek, Susan M.
    Nathanson, Katherine L.
    Garber, Judy E.
    Weitzel, Jeffrey
    Narod, Steven A.
    Tomlinson, Gail
    Olopade, Olufunmilayo I.
    Godwin, Andrew
    Isaacs, Claudine
    Jakubowska, Anna
    Lubinski, Jan
    Gronwald, Jacek
    Gorski, Bohdan
    Byrski, Tomasz
    Huzarski, Tomasz
    Peock, Susan
    Cook, Margaret
    Baynes, Caroline
    Murray, Alexandra
    Rogers, Mark
    Daly, Peter A.
    Dorkins, Huw
    Schmutzler, Rita K.
    Versmold, Beatrix
    Engel, Christoph
    Meindl, Alfons
    Arnold, Norbert
    Niederacher, Dieter
    Deissler, Helmut
    Spurdle, Amanda B.
    Chen, Xiaoqing
    Waddell, Nicola
    Cloonan, Nicole
    Kirchhoff, Tomas
    [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2007, 81 (06) : 1186 - 1200
  • [10] Reproductive and Hormonal Factors, and Ovarian Cancer Risk for BRCA1 and BRCA2 Mutation Carriers: Results from the International BRCA1/2 Carrier Cohort Study
    Antoniou, Antonis C.
    Rookus, Matti
    Andrieu, Nadine
    Brohet, Richard
    Chang-Claude, Jenny
    Peock, Susan
    Cook, Margaret
    Evans, D. Gareth
    Eeles, Rosalind
    Nogues, Catherine
    Faivre, Laurence
    Gesta, Paul
    van Leeuwen, Flora E.
    Ausems, Margreet G. E. M.
    Sorio, Ana
    Caldes, Trinidad
    Simard, Jacques
    Lubinski, Jan
    Gerdes, Anne-Marie
    Olah, Edith
    Fuerhauser, Christine
    Olsson, Hakan
    Arver, Brita
    Radice, Paolo
    Easton, Douglas F.
    Goldgarl, David E.
    [J]. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2009, 18 (02) : 601 - 610
12345678910