Isocitrate dehydrogenase 1: what it means to the neurosurgeon A review

被引：20
|
作者：
Hodges, Tiffany R. [1 ,2 ]
Choi, Bryan D. [1 ,2 ]
Bigner, Darell D. [2 ]
Yan, Hai [2 ]
Sampson, John H. [1 ,2 ]
机构：
[1] Duke Univ, Med Ctr, Div Neurosurg, Dept Surg,Duke Brain Tumor Immunotherapy Program, Durham, NC 27710 USA
[2] Duke Univ, Med Ctr, Preston Robert Tisch Brain Tumor Ctr, Durham, NC 27710 USA
来源：
JOURNAL OF NEUROSURGERY | 2013年 / 118卷 / 06期
基金：
美国国家卫生研究院;
关键词：
isocitrate dehydrogenase 1; glioma; mutation; genetics; oncology; CODON; 132; MUTATION; IDH1; MUTATIONS; BRAIN-TUMORS; MUTANT IDH1; GLIOMAS; LEUKEMIA; GROWTH; CELLS;
D O I：
10.3171/2013.3.JNS122282
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Isocitrate dehydrogenase 1 (IDH1) mutations have been discovered to be frequent and highly conserved in secondary glioblastoma multiforme and lower-grade gliomas. Although IDH1 mutations confer a unique genotype that has been associated with a favorable prognosis, the role of the mutated IDH1 enzyme and its metabolites in tumor initiation and maintenance remains unresolved. However, given that IDH1 mutations are homogeneously expressed and are limited solely to tumor tissue, targeting this mutation could potentially yield novel treatment strategies for patients with glioblastoma multiforme.
引用
收藏
页码：1176 / 1180
页数：5
相关论文
共 50 条
  • [41] Isocitrate dehydrogenase mutations in diffuse gliomas: clinical and aetiological implications
    Gupta, R.
    Webb-Myers, R.
    Flanagan, S.
    Buckland, M. E.
    JOURNAL OF CLINICAL PATHOLOGY, 2011, 64 (10) : 835 - 844
  • [42] Isocitrate Dehydrogenase Mutations in Glioma: Genetics, Biochemistry, and Clinical Indications
    Liu, Yang
    Lang, Fengchao
    Chou, Fu-Ju
    Zaghloul, Kareem A.
    Yang, Chunzhang
    BIOMEDICINES, 2020, 8 (09)
  • [43] Identification of Hedgehog pathway responsive glioblastomas by isocitrate dehydrogenase mutation
    Valadez, J. Gerardo
    Grover, Vandana K.
    Carter, Melissa D.
    Calcutt, M. Wade
    Abiria, Sunday A.
    Lundberg, Christopher J.
    Williams, Thomas V.
    Cooper, Michael K.
    CANCER LETTERS, 2013, 328 (02) : 297 - 306
  • [44] A population-based study of low-grade gliomas and mutated isocitrate dehydrogenase 1 (IDH1)
    Dahlrot, Rikke H.
    Kristensen, Bjarne W.
    Hjelmborg, Jacob
    Herrstedt, Jorn
    Hansen, Steinbjorn
    JOURNAL OF NEURO-ONCOLOGY, 2013, 114 (03) : 309 - 317
  • [45] Isocitrate dehydrogenase 1-mutated human gliomas depend on lactate and glutamate to alleviate metabolic stress
    Lenting, Krissie
    Khurshed, Mohammed
    Peeters, Tom H.
    van den Heuvel, Corina N. A. M.
    van Lith, Sanne A. M.
    de Bitter, Tessa
    Hendriks, Wiljan
    Span, Paul N.
    Molenaar, Remco J.
    Botman, Dennis
    Verrijp, Kiek
    Heerschap, Arend
    ter Laan, Mark
    Kusters, Benno
    van Ewijk, Anne
    Huynen, Martijn A.
    van Noorden, Cornelis J. F.
    Leenders, William P. J.
    FASEB JOURNAL, 2019, 33 (01) : 557 - 571
  • [46] High-throughput immunohistochemical profiling of primary brain tumors and non-neoplastic systemic organs with a specific antibody against the mutant isocitrate dehydrogenase 1 R132H protein
    Ikota, Hayato
    Nobusawa, Sumihito
    Tanaka, Yuko
    Yokoo, Hideaki
    Nakazato, Yoichi
    BRAIN TUMOR PATHOLOGY, 2011, 28 (02) : 107 - 114
  • [47] Integrated analysis of the genomic and transcriptional profile of gliomas with isocitrate dehydrogenase-1 and tumor protein 53 mutations
    Liu, Han-Qing
    Li, Wei-Xin
    An, Ya-Wen
    Wu, Tao
    Jiang, Guang-Yu
    Dong, Yu
    Chen, Wei-Xin
    Wang, Jian-Chun
    Wang, Cheng
    Song, Shuo
    INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY, 2022, 36
  • [48] Role of isocitrate dehydrogenase 1/2 (IDH 1/2) gene mutations in human tumors
    Liu, Xiang
    Ling, Zhi-Qiang
    HISTOLOGY AND HISTOPATHOLOGY, 2015, 30 (10) : 1155 - 1160
  • [49] Discovery of a Novel Chemical Scaffold Against Mutant Isocitrate Dehydrogenase 1 (IDH1)
    Kang, Chung Hyo
    Choi, Sang Un
    Son, You Hwa
    Lee, Heung Kyoung
    Jeong, Hye Gwang
    Yun, Chang-Soo
    Ahn, Sunjoo
    Park, Chi Hoon
    ANTICANCER RESEARCH, 2020, 40 (09) : 4929 - 4935
  • [50] Symptom management in isocitrate dehydrogenase mutant glioma
    Walbert, Tobias
    Avila, Edward K.
    Boele, Florien W.
    Hertler, Caroline
    Lu-Emerson, Christine
    van der Meer, Pim B.
    Peters, Katherine B.
    Rooney, Alasdair G.
    Templer, Jessica W.
    Koekkoek, Johan A. F.
    NEURO-ONCOLOGY PRACTICE, 2024, : i38 - i48
12345