Isocitrate dehydrogenase 1: what it means to the neurosurgeon A review

被引：20

作者：

Hodges, Tiffany R. ^{[1
,2
]}

Choi, Bryan D. ^{[1
,2
]}

Bigner, Darell D. ^{[2
]}

Yan, Hai ^{[2
]}

Sampson, John H. ^{[1
,2
]}

机构：

[1] Duke Univ, Med Ctr, Div Neurosurg, Dept Surg,Duke Brain Tumor Immunotherapy Program, Durham, NC 27710 USA

[2] Duke Univ, Med Ctr, Preston Robert Tisch Brain Tumor Ctr, Durham, NC 27710 USA

来源：

JOURNAL OF NEUROSURGERY | 2013年 / 118卷 / 06期

基金：

美国国家卫生研究院;

关键词：

isocitrate dehydrogenase 1; glioma; mutation; genetics; oncology; CODON; 132; MUTATION; IDH1; MUTATIONS; BRAIN-TUMORS; MUTANT IDH1; GLIOMAS; LEUKEMIA; GROWTH; CELLS;

D O I：

10.3171/2013.3.JNS122282

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Isocitrate dehydrogenase 1 (IDH1) mutations have been discovered to be frequent and highly conserved in secondary glioblastoma multiforme and lower-grade gliomas. Although IDH1 mutations confer a unique genotype that has been associated with a favorable prognosis, the role of the mutated IDH1 enzyme and its metabolites in tumor initiation and maintenance remains unresolved. However, given that IDH1 mutations are homogeneously expressed and are limited solely to tumor tissue, targeting this mutation could potentially yield novel treatment strategies for patients with glioblastoma multiforme.

引用

页码：1176 / 1180

页数：5

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