Synthesis of Polysubstituted Pyrroles via Silver-Catalyzed Oxidative Radical Addition of Cyclopropanols to Imines

被引：20

作者：

Zhou, Yulu ^{[1
]}

Wu, Mingchang ^{[1
]}

Liu, Yi ^{[1
]}

Cheng, Cungui ^{[1
]}

Zhu, Gangguo ^{[1
]}

机构：

[1] Zhejiang Normal Univ, Dept Chem, Minist Educ Adv Catalysis Mat, Key Lab, Jinhua 321004, Zhejiang, Peoples R China

来源：

ORGANIC LETTERS | 2020年 / 22卷 / 19期

基金：

中国国家自然科学基金;

关键词：

ALDEHYDE-DERIVED HYDRAZONES; C-H DIFLUOROALKYLATION; BOND-CLEAVAGE; C(SP(2))-H FUNCTIONALIZATION; KETONES; ACCESS; TRIFLUOROMETHYLATION; PERFLUOROALKYLATION; CONSTRUCTION; CYCLIZATION;

D O I：

10.1021/acs.orglett.0c02735

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A silver-catalyzed formal [3 + 2] cycloaddition reaction, with cyclopropanols as a C3 subunit and imines as a two-atom subunit, is developed. The reaction takes place under mild conditions and produces a broad array of polysubstituted pyrroles in medium to high yields. It represents the first example of oxidative radical addition to imines, thus offering a new choice for the direct C-H functionalization of imines.

引用

页码：7542 / 7546

页数：5

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