Enantiomeric resolution of chiral sulfoxides on polysaccharide phases by HPLC

被引：0
|
作者：
Matlin, SA
Tiritan, ME
Cass, QB
Boyd, DR
机构：
[1] UNIV WARWICK,DEPT CHEM,COVENTRY CV4 7AL,W MIDLANDS,ENGLAND
[2] UNIV FED SAO CARLOS,DEPT CHEM,SAO CARLOS,SP,BRAZIL
[3] QUEENS UNIV BELFAST,SCH CHEM,BELFAST,ANTRIM,NORTH IRELAND
来源：
CHIRALITY | 1996年 / 8卷 / 01期
关键词：
amylose; (S)-alpha-methylbenzyl carbamate; chiral sulfoxides; microporous silica; polysaccharide phases;
D O I：
10.1002/(SICI)1520-636X(1996)8:1<147::AID-CHIR22>3.0.CO;2-M
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The enantiomeric resolution of chiral sulfoxides was investigated on amylose (S)-alpha-methylbenzyl carbamate phase coated on aminopropylated 7 mu m silica with 500 Angstrom diameter pores. This was shown to be very successful in the separation of alkyl/aryl, aryl/aryl, and non-aromatic sulfoxides. The effect of pore size using naked silica was also investigated, demonstrating that the pore size does not affect the resolution. (C) 1996 Wiley-Liss, Inc.
引用
收藏
页码：147 / 152
页数：6
相关论文
共 50 条
  • [1] NEW HPLC-CHIRAL STATIONARY PHASES FOR ENANTIOMERIC RESOLUTION OF SULFOXIDES AND SELENOXIDES
    GARGARO, G
    GASPARRINI, F
    MISITI, D
    PALMIERI, G
    PIERINI, M
    VILLANI, C
    CHROMATOGRAPHIA, 1987, 24 : 505 - 509
  • [2] HPLC enantiomeric resolution of nebivolol on normal and reversed amylose based chiral phases
    Aboul-Enein, HY
    Ali, I
    PHARMAZIE, 2001, 56 (03): : 214 - 216
  • [3] Enantiomeric resolution of kielcorin derivatives by HPLC on polysaccharide stationary phases using multimodal elution
    Sousa, EP
    Tiritan, ME
    Oliveira, RV
    Afonso, CMM
    Cass, QB
    Pinto, MMM
    CHIRALITY, 2004, 16 (05) : 279 - 285
  • [4] HPLC separation of enantiomeric pyrrolidine alcohols and their precursors on polysaccharide-based chiral stationary phases
    Zhou, Ailing
    Lindsay, Harriet A.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2014, 248
  • [5] ENANTIOMERIC RESOLUTION ON HPLC CHIRAL STATIONARY PHASES - INFLUENCE OF AROMATIC INTERACTIONS ON ELUTION ORDER
    NGUYENPHO, AAN
    BRUNNER, CA
    ROSCHER, NM
    DOYLE, TD
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1994, 208 : 85 - ANYL
  • [6] THE ENANTIOMERIC RESOLUTION OF CIPROFIBRATE AND RELATED-COMPOUNDS BY HPLC USING CHIRAL STATIONARY PHASES
    ANDERSON, NH
    JOHNSTON, D
    VOJVODIC, PR
    JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1992, 10 (07) : 501 - 505
  • [7] Enantiomeric resolution of drugs and metabolites in polysaccharide- and protein-based chiral stationary phases
    Bonato, PS
    Bortocan, R
    Gaitani, CM
    Paias, FO
    Iha, MH
    Lima, RP
    JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, 2002, 13 (02) : 190 - 199
  • [8] POLYSACCHARIDE DERIVATIVES AS CHIRAL STATIONARY PHASES IN HPLC
    OKAMOTO, Y
    KAIDA, Y
    HRC-JOURNAL OF HIGH RESOLUTION CHROMATOGRAPHY, 1990, 13 (10): : 708 - 712
  • [9] Impact of immobilized polysaccharide chiral stationary phases on enantiomeric separations
    Ali, I
    Aboul-Enein, HY
    JOURNAL OF SEPARATION SCIENCE, 2006, 29 (06) : 762 - 769
  • [10] Enantiomeric resolution, thermodynamic parameters, and modeling of clausenamidone and neoclausenamidone on polysaccharide-based chiral stationary phases
    Luo, Xuna
    Fang, Chengqiao
    Mi, Junru
    Xu, Jingzi
    Lin, Hansen
    CHIRALITY, 2019, 31 (06) : 423 - 433
12345