A pharmacokinetic study of flumequine in sea bass, Dicentrarchus labrax (L.), after a single intravascular injection

被引：16

作者：

Rigos, G ^{[1
]}

Tyrpenou, A

Nengas, I

Alexis, M

机构：

[1] Natl Ctr Marine Res, Lab Fish Nutr & Pathol, GR-16604 Athens, Greece

[2] Natl Agr Res Fdn, Inst Vet Res Athens, HPLC Residue Anal Lab, Dept Residue Res, Athens, Greece

来源：

JOURNAL OF FISH DISEASES | 2002年 / 25卷 / 02期

关键词：

absorbtion; Dicentrarchus labrax; elimination; flumequine; pharmacokinetics;

D O I：

10.1046/j.1365-2761.2002.00340.x

中图分类号：

S9 [水产、渔业];

学科分类号：

0908 ;

摘要：

The pharmacokinetic properties of flumequine following a single intravascular injection (10 mg kg(-1) fish) were studied in sea bass, Dicentrarchus labrax (L.), 120 g held at 18 degreesC. The absorption half life (t(1/2alpha)) and the elimination half life (t(1/2beta)) of the drug were calculated to be 1.05 and 10.71 h, respectively. Tissue penetration of flumequine seemed to be moderate because both the apparent volume of distribution of the drug at steady-state (V-d(ss)) and the extensive apparent volume of the central compartment (V-c) were found to be small (1.51 and 0.626 L kg(-1)). The mean residence time (MRT) was short (09.73 h) and the total clearance (CLT) Of the drug was rapid (0-156 L kg(-1) h(-1)).

引用

页码：101 / 105

页数：5

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