In Vivo Anti-Tumor Activity of a New Doxorubicin Conjugate via α-Linolenic Acid

被引：18

作者：

Huan, Menglei ^{[2
]}

Cui, Han ^{[2
]}

Teng, Zenghui ^{[2
]}

Zhang, Bangle ^{[2
]}

Wang, Jieping ^{[3
]}

Liu, Xinyou ^{[3
]}

Xia, Hui ^{[4
]}

Zhou, Siyuan ^{[2
]}

Mei, Qibing ^{[1
]}

机构：

[1] Fourth Mil Med Univ, State Adm Tradit Chinese Med, Key Lab Gastrointestinal Pharmacol Chinese Mat Me, Xian 710032, Peoples R China

[2] Fourth Mil Med Univ, Dept Pharmaceut, Xian 710032, Peoples R China

[3] Fourth Mil Med Univ, Tangdu Hosp, Xian 710035, Peoples R China

[4] Peoples Liberat Army Gen Hosp, Affiliated Hosp 1, Dept Thoraciccardio Surg, Beijing 100048, Peoples R China

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2012年 / 76卷 / 08期

关键词：

doxorubicin; alpha-linolenic acid; prodrug; anti-tumor; CANCER-CELLS; FATTY-ACIDS; NANOPARTICLES; CYTOTOXICITY; ENHANCEMENT; DELIVERY; CHITOSAN;

D O I：

10.1271/bbb.120256

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The conventional chemotherapy agent, doxorubicin, is of limited clinical use because of its systemic toxicity toward normal healthy tissue. A new doxorubicin conjugate with alpha-linolenic acid showed good anti-tumor activity with lower toxicity than free doxorubicin and exhibited an active tumor-targeting profile due to the introduction of alpha-linolenic acid which might be an effective tumor-targeting moiety for the modification of chemotherapeutics.

引用

页码：1577 / 1579

页数：3

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