Mutational anc Anticenic Lancsca Tumor Procression anc Cancer Immunotheraoy

被引：71

作者：

Vitale, Ilio ^{[1
,2
]}

Sistigu, Antonella ^{[2
,3
]}

Manic, Gwenola ^{[2
]}

Rudqvist, Nils-Petter ^{[4
]}

Trajanoski, Zlatko ^{[5
]}

Galluzzi, Lorenzo ^{[4
,6
,7
,8
]}

机构：

[1] Univ Roma Tor Vergata, Dept Biol, Rome, Italy

[2] IRCSS Regina Elena Natl Canc Inst, Rome, Italy

[3] Univ Cattolica Sacro Cuore, Ist Patol Gen, Rome, Italy

[4] Weill Cornell Med Coll, Dept Radiat Oncol, New York, NY 10065 USA

[5] Med Univ Innsbruck, Div Bioinformat, Bioctr, Innsbruck, Austria

[6] Sandra & Edward Meyer Canc Ctr, New York, NY 10065 USA

[7] Yale Univ, Sch Med, Dept Dermatol, New Haven, CT 06510 USA

[8] Univ Paris Descartes Paris V, Paris, France

来源：

TRENDS IN CELL BIOLOGY | 2019年 / 29卷 / 05期

关键词：

IMMUNE-CHECKPOINT BLOCKADE; SQUAMOUS-CELL CARCINOMA; MHC CLASS-I; OPEN-LABEL; PD-1; BLOCKADE; LUNG-CANCER; ACQUIRED-RESISTANCE; ADVANCED MELANOMA; SINGLE-ARM; COMPREHENSIVE ANALYSIS;

D O I：

10.1016/j.tcb.2019.01.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Evolving neoplasms accumulate non-synonymous mutations at a high rate, potentially enabling the expression of antigenic epitopes that can be recognized by the immune system. Since they are not covered by central tolerance, such tumor neoantigens (TNAs) should be under robust immune control as they surge. However, genetic defects that impair cancer cell eradication by the immune system coupled with the establishment of local immunosuppression can enable TNA accumulation, which is generally associated with improved clinical sensitivity to various immunotherapies. Here, we explore how tumor-intrinsic factors and immunological processes shape the mutational and antigenic landscape of evolving neoplasms to influence clinical responses to immunotherapy, and propose strategies to achieve robust immunological control of the disease despite disabled immunosurveillance.

引用

页码：396 / 416

页数：21

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