Identification of a Novel HIV-1 Unique CRF01_AE/C Recombinant in Yan'an City, Shaanxi Province

被引：0

作者：

Cheng, Si-Wei ^{[1
]}

Qi, Feng ^{[2
]}

Xie, Ying-Na ^{[3
]}

Wang, Na ^{[2
]}

Chen, Yan-Ping ^{[2
,4
]}

Gao, Li-Li ^{[2
]}

Chen, Xin ^{[3
]}

Zhou, Yan-Heng ^{[1
]}

机构：

[1] Yanan Univ, Shaanxi Engn & Technol Res Ctr Conversat & Utiliz, Coll Life Sci, 580 Shengdi Rd, Yanan 716000, Shaanxi, Peoples R China

[2] Yanan Univ, Affiliated Hosp, Yanan, Shaanxi, Peoples R China

[3] Gannan Med Univ, Sch Basic Med Sci, Dept Pathogen Biol, Ganzhou, Jiangxi, Peoples R China

[4] Yanan Second Peoples Hosp, Yanan, Shaanxi, Peoples R China

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 2020年 / 36卷 / 11期

关键词：

HIV-1; recombinant; genetic diversity; CHINA; MEN; SEX;

D O I：

10.1089/aid.2020.0174

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A wide variety of HIV-1 recombinants are constantly discovered in China. Comprehensively monitoring the genetic diversity of HIV-1 is very essential for understanding the molecular epidemiology and controlling the spread of the HIV-1 epidemic. In this study, we presented a novel HIV-1 unique CRF01_AE/C recombinant (19YA001) isolated from a female patient infected HIV-1 through heterosexual transmission in Yan'an city, Shaanxi province. The near full-length genome analyses showed 19YA001 was divided into two CRF01_AE and one C segments by two breakpoints observed in thevif/vprregion. To date, this is the first report revealing the characteristic of HIV-1 subtype in Yan'an city. And this unique recombinant strain might imply that the genetic diversity of HIV-1 in Yan'an city is complex. However, the sample size is too small. Further larger studies of HIV-1 molecular epidemiology are urgently needed to provide a better understanding of HIV-1 diversity and transmission in this region.

引用

页码：952 / 956

页数：5

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