Discoidin Domain Receptors: Unique Receptor Tyrosine Kinases in Collagen-mediated Signaling

被引：172

作者：

Fu, Hsueh-Liang ^{[1
]}

Valiathan, Rajeshwari R. ^{[1
]}

Arkwright, Richard ^{[1
]}

Sohail, Anjum ^{[1
]}

Mihai, Cosmin ^{[2
,3
]}

Kumarasiri, Malika ^{[4
]}

Mahasenan, Kiran V. ^{[4
]}

Mobashery, Shahriar ^{[4
]}

Huang, Paul ^{[5
]}

Agarwal, Gunjan ^{[2
,3
]}

Fridman, Rafael ^{[1
]}

机构：

[1] Wayne State Univ, Sch Med, Dept Pathol, Detroit, MI 48201 USA

[2] Ohio State Univ, Davis Heart & Lung Res Inst, Columbus, OH 43210 USA

[3] Ohio State Univ, Dept Biomed Engn, Columbus, OH 43210 USA

[4] Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA

[5] Inst Canc Res, Chester Beatty Labs, London SW3 6JB, England

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2013年 / 288卷 / 11期

基金：

英国生物技术与生命科学研究理事会; 美国国家卫生研究院;

关键词：

MAMMARY-GLAND DEVELOPMENT; CELL-MIGRATION; ACTIVATION; DDR1; CANCER; BINDING; INHIBITION; PROTEIN; GROWTH; SRC;

D O I：

10.1074/jbc.R112.444158

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The discoidin domain receptors (DDRs) are receptor tyrosine kinases that recognize collagens as their ligands. DDRs display unique structural features and distinctive activation kinetics, which set them apart from other members of the kinase superfamily. DDRs regulate cell-collagen interactions in normal and pathological conditions and thus are emerging as major sensors of collagen matrices and potential novel therapeutic targets. New structural and biological information has shed light on the molecular mechanisms that regulate DDR signaling, turnover, and function. This minireview provides an overview of these areas of DDR research with the goal of fostering further investigation of these intriguing and unique receptors.

引用

页码：7430 / 7437

页数：8

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