Ion channel associated proteins

被引:106
作者
Sheng, M
Kim, E
机构
[1] HARVARD UNIV, SCH MED, BOSTON, MA 02114 USA
[2] MASSACHUSETTS GEN HOSP, DEPT NEUROBIOL, BOSTON, MA 02114 USA
关键词
D O I
10.1016/S0959-4388(96)80091-2
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Neuronal ion channels are directly associated in vivo with a wide variety of proteins. New classes of channel-associated proteins have been identified recently, including the PSD-95/SAP90 family of channel-clustering molecules acid components of the synaptic vesicle release machinery. Recent findings suggest that non-pore-forming subunits of ion channels may also have cell biological functions independent of their effects on channel electrophysiological properties.
引用
收藏
页码:602 / 608
页数:7
相关论文
共 63 条
[1]   SUBUNIT STRUCTURE AND LOCALIZATION OF DIHYDROPYRIDINE-SENSITIVE CALCIUM CHANNELS IN MAMMALIAN BRAIN, SPINAL-CORD, AND RETINA [J].
AHLIJANIAN, MK ;
WESTENBROEK, RE ;
CATTERALL, WA .
NEURON, 1990, 4 (06) :819-832
[2]  
AOKI C, 1994, J NEUROSCI, V14, P5202
[3]   RAPSYN MAY FUNCTION AS A LINK BETWEEN THE ACETYLCHOLINE-RECEPTOR AND THE AGRIN-BINDING DYSTROPHIN-ASSOCIATED GLYCOPROTEIN COMPLEX [J].
APEL, ED ;
ROBERDS, SL ;
CAMPBELL, KP ;
MERLIE, JP .
NEURON, 1995, 15 (01) :115-126
[4]  
Apel Elizabeth D., 1995, Current Opinion in Neurobiology, V5, P62, DOI 10.1016/0959-4388(95)80088-3
[5]   SYNTAXIN - A SYNAPTIC PROTEIN IMPLICATED IN DOCKING OF SYNAPTIC VESICLES AT PRESYNAPTIC ACTIVE ZONES [J].
BENNETT, MK ;
CALAKOS, N ;
SCHELLER, RH .
SCIENCE, 1992, 257 (5067) :255-259
[6]   Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha 1-syntrophin mediated by PDZ domains [J].
Brenman, JE ;
Chao, DS ;
Gee, SH ;
McGee, AW ;
Craven, SE ;
Santillano, DR ;
Wu, ZQ ;
Huang, F ;
Xia, HH ;
Peters, MF ;
Froehner, SC ;
Bredt, DS .
CELL, 1996, 84 (05) :757-767
[7]   THE RAT-BRAIN POSTSYNAPTIC DENSITY FRACTION CONTAINS A HOMOLOG OF THE DROSOPHILA DISKS-LARGE TUMOR SUPPRESSOR PROTEIN [J].
CHO, KO ;
HUNT, CA ;
KENNEDY, MB .
NEURON, 1992, 9 (05) :929-942
[8]   A POTASSIUM CHANNEL BETA-SUBUNIT RELATED TO THE ALDO-KETO REDUCTASE SUPERFAMILY IS ENCODED BY THE DROSOPHILA HYPERKINETIC LOCUS [J].
CHOUINARD, SW ;
WILSON, GF ;
SCHLIMGEN, AK ;
GANETZKY, B .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (15) :6763-6767
[9]   CA2+ CHANNEL REGULATION BY A CONSERVED BETA-SUBUNIT DOMAIN [J].
DEWAARD, M ;
PRAGNELL, M ;
CAMPBELL, KP .
NEURON, 1994, 13 (02) :495-503
[10]   Crystal structures of a complexed and peptide-free membrane protein-binding domain: Molecular basis of peptide recognition by PDZ [J].
Doyle, DA ;
Lee, A ;
Lewis, J ;
Kim, E ;
Sheng, M ;
MacKinnon, R .
CELL, 1996, 85 (07) :1067-1076