Fe(OTf)3-Catalyzed Aromatization of Substituted 3-Methyleneindoline and Benzofuran Derivatives: A Selective Route to C-3-Alkylated Indoles and Benzofurans

被引：28

作者：

Kundal, Sandip ^{[1
]}

Jalal, Swapnadeep ^{[1
]}

Paul, Kartick ^{[1
]}

Jana, Umasish ^{[1
]}

机构：

[1] Jadavpur Univ, Dept Chem, Kolkata 700032, W Bengal, India

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 2015卷 / 25期

关键词：

Indoles; Benzofurans; Aromatization; Iron; Isomerization; Homogeneous catalysis; ALKYNE; FUNCTIONALIZATION; ALKYLATION; ALKALOIDS;

D O I：

10.1002/ejoc.201500540

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and convenient approach was developed to the selective synthesis of 3-substituted indoles and benzofurans by the isomerization of 3-methyleneindoline and benzofuran derivatives catalyzed by Fe(OTf)(3). The salient features of this method are the easy availability of substrates, high yield, mild reaction conditions, tolerance of a variety of functional groups, and use of an environmentally friendly catalyst. A possible mechanism has also been proposed for the isomerization process.

引用

页码：5513 / 5517

页数：5

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