Fe(OTf)3-Catalyzed Aromatization of Substituted 3-Methyleneindoline and Benzofuran Derivatives: A Selective Route to C-3-Alkylated Indoles and Benzofurans

被引：27
|
作者：
Kundal, Sandip [1 ]
Jalal, Swapnadeep [1 ]
Paul, Kartick [1 ]
Jana, Umasish [1 ]
机构：
[1] Jadavpur Univ, Dept Chem, Kolkata 700032, W Bengal, India
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 2015卷 / 25期
关键词：
Indoles; Benzofurans; Aromatization; Iron; Isomerization; Homogeneous catalysis; ALKYNE; FUNCTIONALIZATION; ALKYLATION; ALKALOIDS;
D O I：
10.1002/ejoc.201500540
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple and convenient approach was developed to the selective synthesis of 3-substituted indoles and benzofurans by the isomerization of 3-methyleneindoline and benzofuran derivatives catalyzed by Fe(OTf)(3). The salient features of this method are the easy availability of substrates, high yield, mild reaction conditions, tolerance of a variety of functional groups, and use of an environmentally friendly catalyst. A possible mechanism has also been proposed for the isomerization process.
引用
收藏
页码：5513 / 5517
页数：5
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