Does poly(ADP-ribosyl)ation regulate the DNA methylation pattern?

被引：35

作者：

Zardo, G

DErme, M

Reale, A

Strom, R

Perilli, M

Caiafa, P

机构：

[1] UNIV AQUILA,DIPARTIMENTO SCI & TECNOL BIOMED,I-67100 LAQUILA,ITALY

[2] UNIV ROMA LA SAPIENZA,DEPT HUMAN BIOPATHOL,I-00185 ROME,ITALY

[3] UNIV ROMA LA SAPIENZA,DEPT BIOCHEM SCI A ROSSI FANELLI,I-00185 ROME,ITALY

[4] CNR,CTR MOL BIOL,ROME,ITALY

来源：

BIOCHEMISTRY | 1997年 / 36卷 / 26期

关键词：

D O I：

10.1021/bi970241s

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The existence of a possible correlation between poly(ADP-ribosyl)ation and DNA methylation processes was investigated. In vivo and in vitro experiments were carried out on L929 mouse fibroblasts preincubated for 24 h with or without 3-aminobenzamide, a well-known inhibitor of poly(ADP-ribose) polymerase. Both experimental approaches evidenced a close relationship between these two important nuclear enzymatic mechanisms, suggesting that the poly(ADP-ribosyl)ated isoform of H1 histone and/or long and branched protein-free ADP-ribose polymers could act as protecting agents against full methylation of the CpG dinucleotides in genomic DNA.

引用

页码：7937 / 7943

页数：7

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