Does poly(ADP-ribosyl)ation regulate the DNA methylation pattern?

被引：35
|
作者：
Zardo, G
DErme, M
Reale, A
Strom, R
Perilli, M
Caiafa, P
机构：
[1] UNIV AQUILA,DIPARTIMENTO SCI & TECNOL BIOMED,I-67100 LAQUILA,ITALY
[2] UNIV ROMA LA SAPIENZA,DEPT HUMAN BIOPATHOL,I-00185 ROME,ITALY
[3] UNIV ROMA LA SAPIENZA,DEPT BIOCHEM SCI A ROSSI FANELLI,I-00185 ROME,ITALY
[4] CNR,CTR MOL BIOL,ROME,ITALY
来源：
BIOCHEMISTRY | 1997年 / 36卷 / 26期
关键词：
D O I：
10.1021/bi970241s
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The existence of a possible correlation between poly(ADP-ribosyl)ation and DNA methylation processes was investigated. In vivo and in vitro experiments were carried out on L929 mouse fibroblasts preincubated for 24 h with or without 3-aminobenzamide, a well-known inhibitor of poly(ADP-ribose) polymerase. Both experimental approaches evidenced a close relationship between these two important nuclear enzymatic mechanisms, suggesting that the poly(ADP-ribosyl)ated isoform of H1 histone and/or long and branched protein-free ADP-ribose polymers could act as protecting agents against full methylation of the CpG dinucleotides in genomic DNA.
引用
收藏
页码：7937 / 7943
页数：7
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