Chemical constituents from Gueldenstaedtia verna and their anti-inflammatory activity

被引：20

作者：

Liu, Xin ^{[1
]}

Yin, Chengle ^{[1
]}

Cao, Yue ^{[1
]}

Zhou, Jinge ^{[2
]}

Wu, Tao ^{[2
]}

Cheng, Zhihong ^{[1
]}

机构：

[1] Fudan Univ, Sch Pharm, Dept Pharmacognosy, Shanghai, Peoples R China

[2] Shanghai Univ Tradit Chinese Med, Inst Chinese Mat Med, Key Lab Standardizat Chinese Med,Minist Educ, Shanghai Key Lab Compound Chinese Med, Shanghai, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2018年 / 32卷 / 10期

基金：

中国国家自然科学基金;

关键词：

Gueldenstaedtia verna; triterpenoid glycoside; anti-inflammatory; inhibition of NO production; INFLAMMATORY RESPONSES; GLYCOSIDES; SEEDS;

D O I：

10.1080/14786419.2017.1320795

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A new triterpenoid glycoside (1) and 15 known compounds (2-16) were isolated from the whole plants of Gueldenstaedtia verna. The new compound (1) was identified as complogenin 22-O--d-glucopyranoside by extensive spectroscopic techniques including 1D (H-1 and C-13) and 2D NMR experiments (HSQC, HMBC and NOESY), HR-DART-MS and chemical methods. Most of the isolates were evaluated for their inhibitory activities on LPS-induced NO production in RAW 264.7 cells. The inhibitory effects of the active compounds, sulphuretin (8) and (22E,24S)-5,8-epidioxy-24-methyl-cholesta-6,9(11),22-trien-3-ol (13), on the production of pro-inflammatory mediators (including IL-6, IL1 and PGE(2)) were further estimated in vitro by ELISA in RAW 264.7 macrophages. [GRAPHICS] .

引用

页码：1145 / 1149

页数：5

共 25 条

[21] New antitumor compounds from Carya cathayensis [J].

Wu, Wei ;

Bi, Xiu-Li ;

Cao, Jia-Qing ;

Zhang, Kai-Qing ;

Zhao, Yu-Qing .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (05) :1895-1898

[22] IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses [J].

Xing, Z ;

Gauldie, J ;

Cox, G ;

Baumann, H ;

Jordana, M ;

Lei, XF ;

Achong, MK .

JOURNAL OF CLINICAL INVESTIGATION, 1998, 101 (02) :311-320

[23] Pterocarpans and triterpenoids from Gueldenstaedtia verna [J].

Yin, Chengle ;

Zhou, Jinge ;

Wu, Yiqing ;

Cao, Yue ;

Wu, Tao ;

Zhang, Shoude ;

Li, Honglin ;

Cheng, Zhihong .

FITOTERAPIA, 2015, 106 :46-54

[24]

Yuldashev M. P., 1989, Chemistry of Natural Compounds, V25, P303, DOI 10.1007/BF00597707

[25]

Zhang Q., 1999, J CHIN PHARM SCI, V8, P237, DOI [10.3321/j.issn:1001-5302.2000.02.014, DOI 10.3321/J.ISSN:1001-5302.2000.02.014]

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