Hexamethyldisilazane-Mediated Amidination of Sulfonamides and Amines with Formamides

被引：7

作者：

Chou, Yu-Chen ^{[1
]}

Lin, Wei-Han ^{[1
]}

Lin, Xiu-Yi ^{[1
]}

Kuo, Chin-Ling ^{[1
]}

Zeng, Wan-Qin ^{[1
]}

Lu, I-Chung ^{[1
]}

Liang, Chien-Fu ^{[1
]}

机构：

[1] Natl Chung Hsing Univ, Dept Chem, Taichung 402, Taiwan

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 87卷 / 22期

关键词：

ONE-POT SYNTHESIS; N-SULFONYLFORMAMIDINES; SULFONYL AMIDINES; TERTIARY-AMINES; TANDEM REACTION; AZIDES; DEHYDROGENATION; DERIVATIVES;

D O I：

10.1021/acs.joc.2c01902

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Hexamethyldisilazane was reacted with formamides to generate N,N-disubstituent formimidamide, after which a reaction with sulfonamides was induced to form sulfonylformami-dines. This protocol can be applied for arylformamidine formation in which anilines are used as substrates under optimized conditions. The advantages of this method are high efficiency, structural diversity in products with good yields, and applicability in large-scale operations.

引用

页码：15327 / 15332

页数：6

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