IL-1β, IL-1Ra and sIL-1RII in the culture supernatants of PMN and PBMC and the serum levels in patients with inflammation and patients with cancer disease of the same location

An inflammation or an other malignant process may create a microenvironment that modulates the production and activity of cytokines and their regulators. In the present study we compared the secretion of IL-1 beta and its regulatory proteins: IL-1Ra and sIL-1RII by PMN and PBMC derived from patients with inflammation and patients with cancer disease of the same location. We also examined the serum levels of these mediators in groups of patients. The results obtained revealed changes in the secretion of IL-1 beta and IL-1Ra which are more characteristic of PMN and PBMC from cancer patients than of the cells from patients with inflammation. In contrast, the secretion of sIL-1RII is more characteristic of PMN and PBMC derived from patients with inflammation. Furthermore, PMN appear to play more significant role in the secretion of IL-1Ra. into the circulation of cancer patients than PBMC. In contrast, PBMC affect to a large extent the secretion of IL-1 beta and sIL-1RII into the circulation of patients with inflammation than PMN. Concluding, the secretion of IL-1 beta and its regulatory proteins may depend on the type of immune cells and the type of the disease.