The chemotherapy-induced peripheral neuropathy outcome measures standardization study: from consensus to the first validity and reliability findings

被引：229

作者：

Cavaletti, G. ^{[1
]}

Cornblath, D. R. ^{[2
]}

Merkies, I. S. J. ^{[3
]}

Postma, T. J. ^{[4
]}

Rossi, E. ^{[5
]}

Frigeni, B. ^{[1
]}

Alberti, P. ^{[1
]}

Bruna, J. ^{[6
]}

Velasco, R. ^{[6
]}

Argyriou, A. A. ^{[7
]}

Kalofonos, H. P. ^{[7
]}

Psimaras, D. ^{[8
]}

Ricard, D. ^{[9
]}

Pace, A. ^{[10
]}

Galie, E. ^{[10
]}

Briani, C. ^{[11
]}

Dalla Torre, C. ^{[11
]}

Faber, C. G. ^{[3
]}

Lalisang, R. I. ^{[12
]}

Boogerd, W. ^{[13
]}

Brandsma, D. ^{[13
]}

Koeppen, S. ^{[14
,15
]}

Hense, J. ^{[14
,15
]}

Storey, D. ^{[16
]}

Kerrigan, S. ^{[16
]}

Schenone, A. ^{[17
]}

Fabbri, S. ^{[17
]}

Valsecchi, M. G. ^{[5
]}

机构：

[1] Univ Milano Bicocca, DNTB, I-20900 Monza, MB, Italy

[2] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

[3] Spaarne Hosp, Univ Med Ctr, Dept Neurol, Maastricht, Netherlands

[4] Vrije Univ Amsterdam Med Ctr, Dept Neurol, Amsterdam, Netherlands

[5] Univ Milano Bicocca, Dept Clin Med & Prevent, Ctr Biostat Clin Epidemiol, I-20900 Monza, MB, Italy

[6] Univ Hosp Bellvitge, Dept Neurol, Unit Neurooncol, Lhospitalet De Llobregat, Spain

[7] Univ Hosp Patras, Div Clin Oncol, Dept Med, Patras, Greece

[8] Hop La Pitie Salpetriere, AP HP, Serv Neurol Mazarin, Paris, France

[9] Hop Val de Grace, Serv Neurol, Serv Sante Armees, Paris, France

[10] Natl Canc Inst Regina Elena, Neurol Unit, Rome, Italy

[11] Univ Padua, Dept Neurosci, Padua, Italy

[12] Maastricht Univ, Med Ctr, GROW Sch Oncol & Dev Biol, Div Med Oncol,Dept Internal Med, Maastricht, Netherlands

[13] Netherlands Canc Inst, Dept Neurooncol, Amsterdam, Netherlands

[14] Univ Essen Gesamthsch, Dept Neurol, Essen, Germany

[15] Univ Essen Gesamthsch, W German Canc Ctr, Essen, Germany

[16] Western Gen Hosp, Edinburgh Ctr Neurooncol, Edinburgh EH4 2XU, Midlothian, Scotland

[17] Univ Genoa, Ctr Excellence Biomed Res, Dept Neurosci Ophthalmol & Genet, Genoa, Italy

来源：

ANNALS OF ONCOLOGY | 2013年 / 24卷 / 02期

关键词：

assessment; chemotherapy; clinimetrics; peripheral neuropathy; reliability; validity; QUALITY-OF-LIFE; GRADUATED TUNING FORK; CLINICAL-TRIALS; EORTC; TOXICITY; NEUROTOXICITY; QLQ-C30; SCALE; SCORE; RESPONSIVENESS;

D O I：

10.1093/annonc/mds329

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating and dose-limiting complication of cancer treatment. Thus far, the impact of CIPN has not been studied in a systematic clinimetric manner. The objective of the study was to select outcome measures for CIPN evaluation and to establish their validity and reproducibility in a cross-sectional multicenter study. After literature review and a consensus meeting among experts, face/content validity were obtained for the following selected scales: the National Cancer Institute-Common Toxicity Criteria (NCI-CTC), the Total Neuropathy Score clinical version (TNSc), the modified Inflammatory Neuropathy Cause and Treatment (INCAT) group sensory sumscore (mISS), the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30, and CIPN20 quality-of-life measures. A total of 281 patients with stable CIPN were examined. Validity (correlation) and reliability studies were carried out. Good inter-/intra-observer scores were obtained for the TNSc, mISS, and NCI-CTC sensory/motor subscales. Test-retest values were also good for the EORTC QLQ-C30 and CIPN20. Acceptable validity scores were obtained through the correlation among the measures. Good validity and reliability scores were demonstrated for the set of selected impairment and quality-of-life outcome measures in CIPN. Future studies are planned to investigate the responsiveness aspects of these measures.

引用

页码：454 / 462

页数：9

共 51 条

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